Factors and their influence on regional cerebral blood flow during nonpulsatile cardiopulmonary bypass.
Factors and their influence on regional cerebral blood flow during nonpulsatile cardiopulmonary bypass.
复制标题
非搏动体外循环过程中局部脑血流的影响因素及其影响。
DOI：
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发表时间：
1984
影响因子：
4.6
通讯作者：
Arthur M. Freeman
中科院分区：
文献类型：
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作者：
A. Govier;J. Reves;R. McKay;R. Karp;G. Zorn;R. Morawetz;L. Smith;Mary Adams;Arthur M. Freeman
在这项研究中，我们检查了低温非搏动体外循环（CPB）期间局部脑血流量（CBF）与平均动脉压、全身血流量、动脉二氧化碳分压（PaCO2）、鼻咽温度和血红蛋白的关系。区域 CBF 通过 67 名接受冠状动脉搭桥手术的患者的氙 133 清除率来确定。 CPB 期间局部 CBF 显着下降（下降 55%），鼻咽温度和 PaCO2 是仅有的两个显着因素（p 小于 0.05）。在由 10 名患者组成的亚组中，泵流量在 1.0 至 2.0 L/min/m2 之间的变化并未显着影响局部 CBF。我们的结论是，低温体外循环期间大脑的自动调节功能得以保留。在体外循环的通常条件下，流量和压力的变化与重要的生理或有害的临床影响无关。
In this study we examined the relationship of regional cerebral blood flow (CBF) to mean arterial pressure, systemic blood flow, partial pressure of arterial carbon dioxide (PaCO2), nasopharyngeal temperature, and hemoglobin during hypothermic nonpulsatile cardiopulmonary bypass (CPB). Regional CBF was determined by clearance of xenon 133 in 67 patients undergoing coronary bypass grafting procedures. There was a significant decrease in regional CBF (55% decrease) during CPB, with nasopharyngeal temperature and PaCO2 being the only two significant factors (p less than 0.05). In a subgroup of 10 patients, variation of pump flow between 1.0 and 2.0 L/min/m2 did not significantly affect regional CBF. We conclude that cerebral autoregulation is retained during hypothermic CPB. Under the usual conditions of CPB, variations in flow and pressure are not associated with important physiological or detrimental clinical affects.