Hepatotoxicity Secondary to Chemotherapy.
Hepatotoxicity Secondary to Chemotherapy.
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DOI：
10.14218/jcth.2014.00011
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发表时间：
2014-06
影响因子：
3.6
通讯作者：
O'Brien CB
中科院分区：
文献类型：
--
作者：
Grigorian A;O'Brien CB
多代执业医师面临的难题是确定癌症化疗患者肝功能检查异常的原因。化疗引起的肝毒性通常是由于不可预测的或特殊的反应。尽管我们对作用机制、药效学以及肝脏与化疗之间的相互关系的理解取得了显著进展，但各种药物肝毒性的潜在病因仍未得到解释。在这里，我们提出了一个简明的综述，广泛的鉴别诊断异常肝功能检查（LFTs）在肿瘤患者。
The difficult problem faced by multiple generation of practicing physicians is determining the cause of abnormal liver function tests in cancer patients on chemotherapy. Hepatotoxicity from chemotherapy occurs frequently from an unpredictable or idiosyncratic reaction. Despite remarkable advances in our understanding of the mechanisms of action, pharmacodynamics, and interrelationships between the liver and chemotherapy, the underlying etiology of hepatic toxicity for various agents remains unexplained. Here, we present a concise review of the broad differential diagnosis for abnormal liver function tests (LFTs) in oncology patients.