The Palau Early Psychosis Study: neurocognitive functioning in high-risk adolescents.
The Palau Early Psychosis Study: neurocognitive functioning in high-risk adolescents.
复制标题
帕劳早期精神病研究：高危青少年的神经认知功能。
DOI：
10.1016/j.schres.2006.08.003
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发表时间：
2007
影响因子：
4.5
通讯作者：
Faraone,StephenV
中科院分区：
文献类型：
--
作者：
Myles-Worsley,Marina;Ord,LisaM;Ngiralmau,Hilda;Weaver,Starla;Blailes,Francisca;Faraone,StephenV
CAPITIVEThe本研究的目的是评估独立和联合影响的遗传风险和临床状态对神经认知功能的青少年从一个人口隔离的精神分裂症和强大的家族聚集的cases.METHODThe主题是310非寻求帮助，药物初治青少年14-19岁的帕劳共和国。样本包括98名遗传高风险（GHR）青少年，其中54名有症状，212名遗传低风险（GLR）青少年，包括113名有症状的临床高风险（GHR）受试者和99名无症状的正常对照。临床评估后进行神经认知测试，包括韦氏记忆量表测试的逻辑，视觉和工作记忆，感知组织和处理速度子测试的WISC-III，CPT-IP措施的持续注意力，和测试的精细和粗神经运动功能。受早期精神病症状影响的仅有两个认知成分是WISC-III知觉组织和空间工作记忆。神经认知缺陷并没有随着精神病理学水平的增加而增加。我们发现遗传风险和临床状况对神经认知功能没有显着的交互作用。结论遗传风险和临床状况对HR青少年的神经认知功能产生独立影响，并且遗传风险的影响比临床状况更广泛。我们的研究结果表明，许多与早期精神病相关的神经认知障碍是遗传介导的，并且可以发生在遗传易感个体中，无论其临床状态如何。然而，视觉空间处理似乎是唯一的新兴的视觉空间学中断。
OBJECTIVEThe purpose of the present study was to evaluate both the independent and joint effects of genetic risk and clinical status on neurocognitive functioning in adolescents from a population isolate with an elevated risk for schizophrenia and strong familial aggregation of cases.METHODThe subjects were 310 non-help seeking, drug-naïve adolescents 14–19 years of age from the Republic of Palau. The sample comprised 98 Genetically High Risk (GHR) adolescents, 54 of whom were symptomatic, and 212 Genetically Low Risk (GLR) adolescents, including 113 Clinically High Risk (CHR) subjects who were symptomatic and 99 normal controls who were non-symptomatic. Neurocognitive testing was conducted after the clinical assessment and included Wechsler Memory Scale tests of logical, visual and working memory, the perceptual organization and processing speed subtests of the WISC-III, CPT-IP measures of sustained attention, and tests of fine and gross neuromotor function.RESULTSGHR adolescents showed impairments in immediate logical memory, verbal working memory, CPT-IP performance, and fine motor skills. The only two cognitive components influenced by the presence of early psychosis symptoms were WISC-III perceptual organization and spatial working memory. Neurocognitive deficits did not increase with increasing levels of psychopathology. We found no significant interactive effects of genetic risk and clinical status on neurocognitive functioning.CONCLUSIONSGenetic risk and clinical status exert independent effects on neurocognitive function in HR adolescents, and genetic risk has a broader impact than clinical status. Our results suggest that many of the neurocognitive impairments associated with early psychosis are genetically mediated and can occur in genetically vulnerable individuals regardless of their clinical status. However, visuospatial processing appears to be uniquely disrupted by emerging symptomatology.