Induction of B lymphocyte proliferation by monoclonal anti-Lyb 2 antibody.
Induction of B lymphocyte proliferation by monoclonal anti-Lyb 2 antibody.
复制标题
单克隆抗 Lyb 2 抗体诱导 B 淋巴细胞增殖。
作者：
B. Subbarao;D. Mosier
LyB 2是一种存在于所有B细胞上的分化抗原，其单克隆抗体已被用于研究LyB 2分子在B细胞活化中的作用。抗LyB 2单克隆抗体（m-抗LyB 2）可将静息B细胞转化为原始细胞，并诱导这些活化B细胞增殖。对抗LyB 2的增殖反应是B细胞的LyB 5+亚群的特性，因为该抗体不能刺激来自表达CBA/N免疫缺陷的小鼠的B细胞。由抗LyB 2激活的B细胞在添加的伴刀豆球蛋白A激活的T细胞的上清液中所含的T细胞替代因子的存在下成熟为抗体分泌细胞。因此，在B淋巴细胞活化的早期阶段，LyB 2分子可能参与刺激信号的传递。
Monoclonal antibody to Lyb 2, a differentiation antigen present on all B cells, has been used to study the role of Lyb 2 molecules in B cell activation. Monoclonal anti-Lyb 2 antibody (m-anti-Lyb 2) transforms resting B cells into blast cells and induces proliferation in these activated B cells. The proliferative response to anti-Lyb 2 is a property of the Lyb 5+ subset of B cells, since the antibody fails to stimulate B cells from mice expressing the CBA/N immune defect. B cells activated by anti-Lyb 2 mature into antibody-secreting cells in the added presence of T cell-replacing factors contained in the supernatants from concanavalin A-activated T cells. Thus, Lyb 2 molecules may participate in the delivery of stimulatory signals during the early phases of B lymphocyte activation.