The BACK domain in BTB-kelch proteins
The BACK domain in BTB-kelch proteins
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DOI：
10.1016/j.tibs.2004.10.003
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发表时间：
2004-12-01
影响因子：
13.8
通讯作者：
Privé, GG
中科院分区：
文献类型：
--
作者：
Stogios, PJ;Privé, GG
在大多数同时包含BTB结构域和Kelch重复序列的蛋白质中，都发现了一个新的保守基序-Back(针对BTB和C-末端Kelch)结构域。许多Ketch-Repeat蛋白通过与肌动蛋白和中间丝的相互作用参与细胞骨架的组织，而BTB结构域具有多种细胞作用，包括募集到E3泛素连接酶复合体。BTB和Kelch蛋白中BTB和Kelch蛋白的背部结构域的鉴定以及它在后生动物基因组中的高度保守性，表明该结构域具有重要的功能，可能在基于cullin3的E3连接酶复合体的底物定位中发挥作用。
A novel conserved motif - the BACK (for BTB and C-terminal Kelch) domain - is found in the majority of proteins that contain both the BTB domain and kelch repeats. Many ketch-repeat proteins are involved in organization of the cytoskeleton via interaction with actin and intermediate filaments, whereas BTB domains have multiple cellular roles, including recruitment to E3 ubiquitin ligase complexes. The identification of the BACK domain in BTB and kelch proteins, and its high conservation across metazoan genomes, suggest an important function for this domain with a possible role in substrate orientation in Cullin3-based E3 ligase complexes.