Sequential activation of ground pads reduces skin heating during radiofrequency tumor ablation: in vivo porcine results.
Sequential activation of ground pads reduces skin heating during radiofrequency tumor ablation: in vivo porcine results.
复制标题
接地垫的顺序激活可减少射频肿瘤消融过程中的皮肤加热：猪体内结果。
DOI：
10.1109/tbme.2009.2033385
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发表时间：
2010
期刊：
影响因子：
--
通讯作者：
Haemmerich,Dieter
中科院分区：
文献类型：
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作者：
Schutt,DavidJ;Swindle,MMichael;Helke,KristiL;Bastarrika,Gorka;Schwarz,Florian;Haemmerich,Dieter
单极RF消融期间接地垫下方的皮肤灼伤越来越普遍，从而阻碍了能够与多个或新的施加器组合创建更大肿瘤消融区的更高功率RF发生器的开发。我们的目标是在活体猪模型中评价通过额外的接地垫降低皮肤温度的效果。同时或顺序激活放置在动物腹部的三个接地垫，其中调节激活时间以平衡每个垫下方的皮肤温度。通过放置在猪臀大肌内的两个内冷集束电极进行13次射频消融（n= 4，300 W同时，n= 5，300 W顺序，n = 4，375 W顺序）12 min。通过组织学测定，比较每个垫的温升和烧伤程度。通过T2加权MRI确定消融区大小。同时激活组的最大温升显著高于顺序激活组（21.4°C vs 8.1°C或9.6°C，p < 0.01）。同时（300 W）和顺序激活（300和375 W）期间的消融区直径分别为6.9 ± 0.3、5.6 ± 0.3和7.5 ± 0.6 cm。如组织学检查所测量的，多个接地垫的顺序激活导致显著较低的皮肤温度和较不严重的烧伤。
Skin burns below ground pads during monopolar RF ablation are increasingly prevalent, thereby hindering the development of higher power RF generators capable of creating larger tumor ablation zones in combination with multiple or new applicators. Our goal was to evaluate reduction in skin temperatures via additional ground pads in anin vivoporcine model. Three ground pads placed on the animal's abdomen were activated either simultaneously or sequentially, where activation timing was adjusted to equilibrate skin temperature below each pad. Thirteen RF ablations (n= 4 simultaneous at 300 W,n= 5 sequential at 300 W, andn= 4 sequential at 375 W) were performed for 12 min via two internally cooled cluster electrodes placed in the gluteus maximus of domestic swine. Temperature rise at each pad and burn degree as determined via histology were compared. Ablation zone size was determined via T2-weighted MRI. Maximum temperature rise was significantly higher with simultaneous activation than with either of the sequential activation group (21.4°C versus 8.1°C or 9.6°C, p < 0.01). Ablation zone diameters during simultaneous (300 W) and sequential activations (300 and 375 W) were and 6.9 ± 0.3, 5.6 ± 0.3, and 7.5 ± 0.6 cm, respectively. Sequential activation of multiple ground pads results in significantly lower skin temperatures and less severe burns, as measured by histological examination.