Vitamin D and muscle.
Vitamin D and muscle.
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DOI：
10.1016/j.bonr.2018.04.004
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发表时间：
2018-06
期刊：
影响因子：
2.5
通讯作者：
Girgis CM
中科院分区：
文献类型：
--
作者：
Gunton JE;Girgis CM
人们越来越认识到维生素D在正常肌肉功能中起着重要作用。维生素D水平低与跌倒和近端虚弱的风险增加有关。由于维生素D缺乏症很常见，而且症状不具有特异性，因此在肌肉疼痛和无力的患者中保持对维生素D缺乏症的高度怀疑是很重要的，而且测量血清25（OH）维生素D很简单。治疗是廉价、安全有效的，但有时可能需要更大的剂量，而且，正如我们的病例报告所示，人们愿意支付非处方药物可能是一个问题。以下是一个引人注目的案例报告，证明了严重维生素D缺乏症的肌肉缺陷，我们讨论了临床研究，检查维生素D对身体表现，肌肉力量和跌倒的具体影响。最后，我们提出了分子机制的概述，解释维生素D对肌肉的生物学效应。低维生素D与跌倒和近端虚弱的风险增加有关。治疗是便宜、安全、有效的，但可能需要更大的剂量，并且愿意支付非处方药物可能是一个问题。我们提出了分子机制的概述，解释维生素D对肌肉的生物效应。
Vitamin D is increasingly recognised to play an important role in normal muscle function. Low vitamin D status is associated with an increased risk of falls and proximal weakness. Since vitamin D deficiency is very common, and the signs are non-specific, it is important to maintain a high index of suspicion of vitamin D deficiency in patients with muscle pain and weakness, and it is simple to measure serum 25(OH) vitamin D. Therapy is cheap, safe and effective, but sometimes a larger dose may be needed, and, as shown in our case report, willingness of people to pay for an over the counter medication can be an issue. Following a striking case report that demonstrates muscle defects in severe vitamin D deficiency, we discuss clinical studies examining specific effects of vitamin D on physical performance, muscle strength and falls. Finally, we present an overview of molecular mechanisms that explain vitamin D's biological effects on muscle. Low vitamin D is associated with an increased risk of falls and proximal weakness. Therapy is cheap, safe and effective, but larger doses may be needed and willingness to pay for over the counter medications can be an issue. We present an overview of molecular mechanisms that explain vitamin D’s biological effects on muscle.