Resolution of hypoxic tissue in cerebellar hemispheres after arterial bypass surgery in a patient with symptomatic bilateral vertebral artery occlusion: A 18F-FRP170 PET study.
Resolution of hypoxic tissue in cerebellar hemispheres after arterial bypass surgery in a patient with symptomatic bilateral vertebral artery occlusion: A 18F-FRP170 PET study.
复制标题
有症状的双侧椎动脉闭塞患者动脉搭桥手术后小脑半球缺氧组织的解决：一项 18F-FRP170 PET 研究。
DOI：
10.1097/rlu.0000000000002469
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Ogasawara K.
中科院分区：
文献类型：
--
作者：
Oikawa K;Kobayashi M;Beppu T;Terasaki K;Ogasawara K.
一名 48 岁男性患有复发性眩晕，抗血小板药物治疗无效。脑血管造影显示双侧椎动脉闭塞，侧支循环不良。使用 15 O 2 气体的 PET 显示双侧小脑半球的血流量和氧代谢率降低，氧提取分数升高。随后的 18 F-FRP170（1-（2-18 F-氟-1-[羟甲基]乙氧基）甲基-2-硝基咪唑）PET 描绘了缺氧但存活的组织，显示相同区域的示踪剂摄取升高。颞浅动脉-大脑后动脉吻合术后，15 O-gas PET 显示双侧小脑半球血流、氧代谢率和氧提取分数正常化。这些区域中 18 F-FRP-170 摄取异常升高的问题也得到解决。
A 48-year-old man experienced recurrent vertigo refractory to antiplatelet medications. Cerebral angiography showed occlusion of bilateral vertebral arteries with poor collateral circulation. PET using 15 O 2 gas showed reduced blood flow and metabolic rate of oxygen and elevated oxygen extraction fraction in bilateral cerebellar hemispheres. Subsequent 18 F-FRP170 (1-(2-18 F-fluoro-1-[hydroxymethyl] ethoxy) methyl-2-nitroimidazole) PET, which depicts hypoxic but viable tissue, revealed elevated tracer uptake in the same regions. After superficial temporal artery-posterior cerebral artery anastomosis, 15 O-gas PET showed normalization of blood flow, metabolic rate of oxygen, and oxygen extraction fraction in bilateral cerebellar hemispheres. Abnormally elevated 18 F-FRP-170 uptake was also resolved in those regions.