Effects of isoproterenol on chemical carcinogenesis with DMBA in mouse salivary glands.
Effects of isoproterenol on chemical carcinogenesis with DMBA in mouse salivary glands.
复制标题
异丙肾上腺素对小鼠唾液腺中 DMBA 化学致癌作用的影响。
DOI：
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发表时间：
1979
期刊：
影响因子：
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通讯作者：
Y. Okada
中科院分区：
文献类型：
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作者：
Y. Okada
Histopathological studies were conducted on experimental carcinogenesis in mouse salivary glands using D L-isoproterenol hydochloride (isoproterenol) and 9 10-dimethyl-1 2-benzanthracene (DMBA). DMBA was administered once at 1 mg/0.02 ml in olive oil to the salivary glands, and isoproterenol was injected intraperitoneally at 1 mg/0.05 ml saline solution three times a week for 2 weeks at different periods during the oncogenic process. Salivary glands treated with carcinogen showed a relatively constant sequence of changes and developed epithelial and mesenchymal tumors irrespective of isoproterenol administration. Isoproterenol did not influence the development of another type of tumor; however, it did retard the oncogenic processes.
