How the centriole builds its cilium: of mothers, daughters, and the acquisition of appendages
How the centriole builds its cilium: of mothers, daughters, and the acquisition of appendages
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DOI：
10.1016/j.sbi.2020.09.006
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发表时间：
2021-02-01
影响因子：
6.8
通讯作者：
Reiter, Jeremy
中科院分区：
文献类型：
--
作者：
Kumar, Dhivya;Reiter, Jeremy
中心粒是真核细胞中基于微管的结构。从间期组织细胞微管骨架到有丝分裂时聚焦纺锤体，中心粒在细胞周期的各个阶段都很忙碌。中心粒的一个重要间期功能是聚集纤毛，纤毛是微管状突起，可以是活动的，也可以是不活动的。运动纤毛在精子运动和细胞外液体的推进中起作用，如在肺粘液流动中。固定的初级纤毛对某些形式的细胞间信号传导至关重要。在这里，我们回顾了前中心粒如何成熟为子中心粒，然后是母中心粒。我们强调了纤毛发生的关键步骤，包括母中心粒获得附属物，以及远端中心粒，这是一个对纤毛发生至关重要的研究领域。重要的是，在纤毛病中发生突变的几个基因编码远端中心成分。我们建议，了解中心粒如何重塑以支持纤毛组装将为纤毛病的分子病因提供见解。
Centrioles are microtubule-based structures in eukaryotic cells. From organizing the microtubule cytoskeleton during interphase to focusing the mitotic spindle during mitosis, centrioles are busy at all stages of the cell cycle. One crucial interphase function of centrioles is to assemble cilia, microtubular projections that can either be motile or nonmotile. Motile cilia function in sperm locomotion and propulsion of extracellular fluids, as in mucus flow in the lung. Immotile primary cilia are critical for some forms of intercellular signaling. Here, we review how procentrioles mature into daughter and, then, mother centrioles. We highlight key steps in ciliogenesis, including the acquisition of appendages by the mother centriole, as well as the distal centriole, an understudied domain critical for ciliogenesis. Importantly, several genes mutated in ciliopathies encode distal centriolar components. We propose that understanding how centrioles are remodeled to support cilium assembly will provide insights into the molecular etiologies of ciliopathies.