The timing of external input controls the sign of plasticity at local synapses
The timing of external input controls the sign of plasticity at local synapses
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DOI：
10.1038/nn.2388
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发表时间：
2009-10-01
影响因子：
25
通讯作者：
Paulsen, Ole
中科院分区：
文献类型：
--
作者：
Kwag, Jeehyun;Paulsen, Ole
大脑中的局部网络存储来自外部传入输入的信息的方法还没有被很好地理解。我们发现，传入输入的时间可以双向控制大鼠海马区局部突触的脉冲时间依赖性可塑性的标志。这一机制提供了一种方法，通过该方法，外部输入中的时间信息可以被编码到突触权重的局部矩阵中。
The method by which local networks in the brain store information from extrinsic afferent inputs is not well understood. We found that the timing of afferent input can bidirectionally control the sign of spike timing-dependent plasticity at local synapses in rat hippocampus. This mechanism provides a means by which temporal information in external input can be encoded in the local matrix of synaptic weights.