A synthetic analogue of vitamin D3, 22-oxa-1 alpha,25-dihydroxyvitamin D3, is a potent modulator of in vivo immunoregulating activity without inducing hypercalcemia in mice.
A synthetic analogue of vitamin D3, 22-oxa-1 alpha,25-dihydroxyvitamin D3, is a potent modulator of in vivo immunoregulating activity without inducing hypercalcemia in mice.
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维生素 D3 的合成类似物 22-oxa-1 α,25-二羟基维生素 D3 是体内免疫调节活性的有效调节剂，不会引起小鼠高钙血症。
DOI：
10.1210/endo-124-5-2645
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发表时间：
1989
期刊：
影响因子：
4.8
通讯作者：
Y. Nishii
中科院分区：
文献类型：
--
作者：
J. Abe;Y. Takita;T. Nakano;C. Miyaura;T. Suda;Y. Nishii
在小鼠中比较了4种侧链含氧原子的维生素D3合成类似物与1 α，25-二羟基维生素D3 [1 α，25（OH）2D 3]的体内免疫调节活性和高钙作用。这些维生素D3化合物的口服给药增强了初级免疫应答，诱导免疫接种与次优数量的绵羊红细胞，而不诱导高钙血症。诱导免疫应答的体内效力顺序为22-oxa-1 α，25（OH）2D 3大于1 α，25（OH）2D 3不等于20-oxa-1 α，25（OH）2D 3不等于22-oxa-1 α（OH）D3大于1 α（OH）D3不等于20-oxa-1 α（OH）D3。22-Oxa-1 α，25（OH）_2D_3在诱导体内初次免疫应答方面的效力比1 α，25（OH）_2D_3强约50倍，但前者在诱导高钙血症方面的活性仅为后者的1/100。这些结果表明，维生素D化合物的免疫调节活性可以从结构上与其体内高钙作用分离。
The in vivo immunoregulating activity and the hypercalcemic action of 4 synthetic analogues of vitamin D3 with an oxygen atom in the side chain were compared with those of 1 alpha,25-dihydroxyvitamin D3 [1 alpha,25(OH)2D3] in mice. Oral administration of these vitamin D3 compounds augmented the primary immune response, induced by immunization with a suboptimal number of sheep erythrocytes, without inducing hypercalcemia. The order of the in vivo potency to induce the immune response was 22-oxa-1 alpha,25(OH)2D3 greater than 1 alpha,25(OH)2D3 not equal to 20-oxa-1 alpha,25(OH)2D3 not equal to 22-oxa-1 alpha(OH)D3 greater than 1 alpha(OH)D3 not equal to 20-oxa-1 alpha(OH)D3. 22-Oxa-1 alpha,25(OH)2D3 was about 50 times more potent than 1 alpha,25(OH)2D3 in inducing the in vivo primary immune response, but the former was only 1/100 as active as the latter in inducing hypercalcemia. These results suggest that the immunoregulating activity of vitamin D compounds can be separated structurally from their hypercalcemic action in vivo.