Treatments for diabetic neuropathy.
Treatments for diabetic neuropathy.
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DOI：
10.1007/s11892-001-0024-8
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发表时间：
2001-10-01
影响因子：
4.2
通讯作者：
Boulton, A J
中科院分区：
文献类型：
--
作者：
Boulton, A J
症状性糖尿病感觉神经病变的治疗对执业医生提出了一个治疗挑战。本文概述了两种方法。首先，讨论了不会影响痛性神经病的自然病史的对症治疗。除了稳定的血糖控制外，这些药物还包括三环类药物、一些抗惊厥和抗心律失常药物以及阿片类药物。局部治疗和非药理学方法也被讨论。除了接近正常的血糖，可能减缓神经病进展的治疗方法都是实验性的，包括醛糖还原酶抑制剂、抗氧化剂和其他药物。最后，对无症状但感觉丧失的患者的治疗方法进行了讨论。
The management of symptomatic diabetic sensory neuropathy presents a therapeutic challenge to the practicing physician. Two approaches are outlined in this article. First, symptomatic therapies, which will not influence the natural history of painful neuropathy, are discussed. These include, in addition to the stable glycemic control, tricyclic drugs, a number of anticonvulsant and antiarrhythmic agents, and opioid-like medications. Topical therapies and nonpharmalogic approaches are also discussed. With the exception of near normoglycemia, treatments that may slow the progression of neuropathy are experimental and include aldose reductase inhibitors, antioxidants, and other agents. Finally, the approach to patients without symptoms but with sensory loss is discussed.