Autism in African American families: Clinical-phenotypic findings
Autism in African American families: Clinical-phenotypic findings
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DOI：
10.1002/ajmg.b.30535
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发表时间：
2007-12-05
影响因子：
2.8
通讯作者：
Pericak-Vance, Margaret A.
中科院分区：
文献类型：
--
作者：
Cuccaro, Michael L.;Brinkley, Jason;Pericak-Vance, Margaret A.
与其他复杂疾病不同，自闭症的研究几乎仅限于白人家庭。这项研究代表了第一次努力，以检查临床和表型的结果，在个人与自闭症的非洲裔美国人家庭。从一个正在进行的自闭症遗传学研究中，我们比较了非裔美国人（N=46，平均年龄=118个月）和白人（N=298，平均年龄=105个月）组的自闭症症状和发育性语言症状。非裔美国人组在语言方面表现出更大的延迟，但在核心自闭症症状上与白人组没有差异。这些发现，虽然提示更严重的表型，可能反映了一个确定的偏见。尽管如此，我们认为，应该进行更多的种族-种族群体的研究，并考虑到几个目标，包括加强招募策略，以包括更多的种族-种族群体和更周到的表型特征评估。这样的考虑将极大地帮助寻找自闭症的遗传变异。(c)2007 Wiley-Liss，Inc.
Unlike other complex diseases, the study of autism has been almost exclusively limited to Caucasian families. This study represents a first effort to examine clinical and phenotypic findings in individuals with autism from African American families. Drawing from an ongoing genetic study of autism we compared African American (N=46, mean age=118 months) and Caucasian (N=298, mean age=105 months) groups on autism symptoms and developmental language symptoms. The African American group showed greater delays in language but did not differ from the Caucasian group on core autism symptoms. These findings, while suggestive of a more severe phenotype, may reflect an ascertainment bias. Nonetheless, we believe that more studies of racial-ethnic groups should be conducted with several goals in mind including strengthening recruiting strategies to include more ethnic-racial groups and more thoughtful evaluation of phenotypic traits. Such considerations will aid greatly in the search for genetic variants in autism. (c) 2007 Wiley-Liss, Inc.