Solubility of 5-Amino Salicylic Acid in Different Solvents at Various Temperatures
Solubility of 5-Amino Salicylic Acid in Different Solvents at Various Temperatures
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DOI：
10.1021/je900646u
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发表时间：
2010-01
影响因子：
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通讯作者：
Ashish Patel;Arun Vaghasiya;R. Gajera;S. Baluja
中科院分区：
文献类型：
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作者：
Ashish Patel;Arun Vaghasiya;R. Gajera;S. Baluja
用重量法测定了5-氨基水杨酸在甲醇、乙醇、四氯化碳和四氢呋喃（THF）中的溶解度，并对溶解度与温度的关系进行了关联。溶解度大小顺序为THF >四氯化碳>乙醇>甲醇。此外，一些热力学参数，如焓，吉布斯能量，和熵也已被评估的溶解过程。据观察，焓和熵是积极的，而吉布斯活化能是负的所有四种溶剂。负的吉布斯能量表明溶解过程的自发性质，而正的焓表明化合物的吸热溶解。正熵是由于在所研究的溶剂中有利的溶解。
The solubility data of 5-amino salicylic acid in methanol, ethanol, carbon tetrachloride, and tetrahydrofuran (THF) at various temperatures were measured by gravimetrical method from (293.15 to 313.15) K under atmospheric pressure, and the solubility data were correlated as a function of temperature. The order of solubility is THF > carbon tetrachloride > ethanol > methanol. Further, some thermodynamic parameters such as enthalpy, Gibb’s energy, and entropy have also been evaluated for the dissolution process. It is observed that enthalpy and entropy are positive, whereas the Gibb’s energy of activation is negative for all of the four solvents. The negative Gibb’s energy suggests the spontaneous nature of dissolution process, whereas positive enthalpy indicates endothermic dissolution of compounds. The positive entropy is due to favorable dissolution in the studied solvents.