Fetal kidney charts of a novel measurement of the renal parenchymal thickness to evaluate fetal kidney growth and potential function
Fetal kidney charts of a novel measurement of the renal parenchymal thickness to evaluate fetal kidney growth and potential function
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DOI：
10.1002/pd.5701
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发表时间：
2020-04-23
影响因子：
3
通讯作者：
Watson, David
中科院分区：
文献类型：
--
作者：
Brennan, Sonja;Kandasamy, Yogavijayan;Watson, David
目的建立胎儿肾实质厚度、长度和体积的新标准生长曲线，以确定临床使用的正常范围，并评估这些测量的可靠性。方法对72例每4周至少进行一次连续超声检查的低风险单胎妊娠进行前瞻性纵向研究。在每次扫描时，对两个肾脏进行多次肾脏测量。在正中矢状面测量肾实质厚度。结果建立了胎儿肾实质厚度、长度和体积的标准图。结论提出了一种新的胎儿肾实质发育图，能够反映胎儿肾实质在妊娠期间的生长发育情况。在临床实践中，它们将有助于识别这些正常范围内的任何变化，这可能是辅助产前诊断肾脏病理和未来预测肾功能的研究的重要标准。
Objective The objective of this study was to develop new standard growth charts for fetal renal parenchymal thickness, length, and volume to define normal ranges for use in clinical practice and to assess the reliability of these measurements.Methods This was a prospective, longitudinal study of 72 low-risk singleton pregnancies undergoing serial ultrasound examinations at least every four weeks. Multiple renal measurements were performed on both kidneys at each scan. The renal parenchymal thickness was measured in the mid-sagittal plane. Standard charts were developed and the intra and interobserver reliability for the renal measurements was analysed.Results Standard charts were developed for fetal renal parenchymal thickness, length, and volume.Conclusion We present novel charts, which demonstrate the growth of the fetal renal parenchyma during pregnancy. They will be useful in clinical practice to identify any alterations from these normal ranges, which may be an important criterion for assisting prenatal diagnosis of renal pathologies and future studies in the prediction of kidney function.