DETECTION AND STAGING OF DEMENTIA IN ALZHEIMERS-DISEASE - USE OF THE NEUROPSYCHOLOGICAL MEASURES DEVELOPED FOR THE CONSORTIUM TO ESTABLISH A REGISTRY FOR ALZHEIMERS-DISEASE
DETECTION AND STAGING OF DEMENTIA IN ALZHEIMERS-DISEASE - USE OF THE NEUROPSYCHOLOGICAL MEASURES DEVELOPED FOR THE CONSORTIUM TO ESTABLISH A REGISTRY FOR ALZHEIMERS-DISEASE
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DOI：
10.1001/archneur.1992.00530290030008
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发表时间：
1992-05-01
影响因子：
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通讯作者：
HEYMAN, A
中科院分区：
文献类型：
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作者：
WELSH, KA;BUTTERS, N;HEYMAN, A
我们早期的研究使用了建立阿尔茨海默病神经心理电池登记的联盟，表明延迟回忆是早期阿尔茨海默病的高度敏感指标。没有一个学习和记忆的措施，在电池被发现是有用的分期这种形式的痴呆症的严重程度。这项研究探讨了非记忆功能（流畅性，命名和实践）的联盟建立阿尔茨海默病电池的登记，并询问是否对任何这些措施的性能增加了早期阿尔茨海默病的检测或对疾病的后期进展敏感。我们根据严重程度（轻度、中度、重度）对患有这种疾病的患者进行分层，并将其与年龄、教育程度和性别匹配的对照受试者（每组N = 49）进行比较。多变量程序和切割分数被用来确定各种措施的有效性，区分病例和对照组。延迟回忆障碍再次被发现是检测轻度阿尔茨海默病的最佳方法。对抗命名是唯一的非记忆因素，有助于这种歧视。对于疾病的分期，包括流畅性，实践和识别记忆的措施的组合最好区分轻度痴呆症的病例与中度或重度疾病的病例。在阿尔茨海默病患者中，延迟回忆的测量很快就“触底”了，并且证明对疾病分期没有什么价值。这些研究结果是一致的，报告的病理进展的疾病，并建议，而延迟回忆记忆是一个高度敏感的指标阿尔茨海默氏病，词汇语义处理和视觉空间功能是更好的决定因素，这种疾病的进展过程。
Our earlier studies using the Consortium to Establish a Registry of Alzheimer's Disease neuropsychological battery showed that delayed recall was a highly sensitive indicator of early Alzheimer's disease. None of the learning and memory measures in the battery were found to be useful in staging the severity of this form of dementia. This study explores the nonmemory functions (fluency, naming, and praxis) of the Consortium to Establish a Registry of Alzheimer's Disease battery and asks whether performance on any of these measures adds to the detection of early Alzheimer's disease or is sensitive to the later progression of the illness. We stratified patients with this disease according to severity (mild, moderate, severe), and compared them with age-, education-, and gender-matched control subjects (group N = 49 each). Multivariate procedures and cutting scores were used to determine the efficacy of the various measures in distinguishing between the cases and control subjects. Impairment of delayed recall was again found to be the best discriminator for detecting mild cases of Alzheimer's disease. Confrontation naming was the only nonmemory factor that assisted in this discrimination. For staging the illness, a combination of measures including fluency, praxis, and recognition memory best differentiated cases with mild dementia from those with either moderate or severe stages of disease. Measures of delayed recall quickly "bottomed out" in the patients with Alzheimer's disease and proved of little value in staging the disorder. These findings are consistent with the reported pathologic progression of the illness and suggest that whereas delayed recall memory is a highly sensitive indicator of Alzheimer's disease, lexical-semantic processing and visuospatial functions are better determinants of the progressive course of this illness.