IMMUNITY INDUCED BY PRIMARY HUMAN CYTOMEGALOVIRUS-INFECTION PROTECTS AGAINST SECONDARY INFECTION AMONG WOMEN OF CHILDBEARING AGE
IMMUNITY INDUCED BY PRIMARY HUMAN CYTOMEGALOVIRUS-INFECTION PROTECTS AGAINST SECONDARY INFECTION AMONG WOMEN OF CHILDBEARING AGE
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DOI：
10.1093/infdis/171.1.26
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发表时间：
1995-01-01
影响因子：
6.4
通讯作者：
BEST, AM
中科院分区：
文献类型：
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作者：
ADLER, SP;STARR, SE;BEST, AM
为了确定对人类巨细胞病毒（HCMV）的免疫力是否可以保护妇女免受子女的侵害，使用了盲人，随机方案来监测接受安慰剂或镇疫苗（类似于500 PFU）和血清阳性妇女的血清负体女性和妇女。每组的平均母亲（33岁）和儿童年龄（18个月）和儿童病毒脱落持续时间（15个月）相似。在19名安慰剂接受者中，有9例发育为原发性感染。 19个疫苗中有8个，但只有42名自然血清阳性受试者中只有3个有证据表明从孩子那里获取HCMV。野生型感染和Towne疫苗对HCMV抗原产生了相似的平均淋巴细胞增生反应，但是一剂Towne疫苗产生的平均中和滴度比野生型感染后低10至20倍。因此，一种诱导与野生型病毒诱导的免疫反应的疫苗可以保护健康的女性免于从子女中获取HCMV。
To determine if immunity to human cytomegalovirus (HCMV) protects women from acquiring HCMV from their children, a blinded, randomized protocol was used to monitor seronegative women who received placebo or Towne vaccine (similar to 500 pfu) and seropositive women. Each group was similar for mean maternal (33 years) and child age (18 months) and duration of viral shedding by the child (15 months). Among 19 placebo recipients, 9 developed primary infection; 8 of 19 vaccinees but only 3 of 42 naturally seropositive subjects had evidence of acquiring HCMV from their child. Wild type infection and Towne vaccine induced similar mean lymphoproliferative responses to HCMV antigens, but one dose of Towne vaccine produced mean neutralizing titers 10- to 20-fold lower than those after wild type infection. Thus, a vaccine that induces immune responses equal to those induced by wild type virus may protect healthy women from acquiring HCMV from their children.