Effect of aging on serum uric acid levels: Longitudinal changes in a large Japanese population group
Effect of aging on serum uric acid levels: Longitudinal changes in a large Japanese population group
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DOI：
10.1093/gerona/57.10.m660
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发表时间：
2002-10-01
影响因子：
5.1
通讯作者：
Shimokata, H
中科院分区：
文献类型：
--
作者：
Kuzuya, M;Ando, F;Shimokata, H
背景。血清尿酸（SUA）不仅与痛风风险增加有关，而且与心血管疾病风险增加有关。然而，SUA 与年龄相关的真正变化仍然未知。方法。 1989年至1998年间，在健康检查中心对SUA、体重指数（BMI）和酒精摄入量的流行病学随访数据进行了纵向人群研究。研究对象为80,506名日本上班族或其家庭（男性50,157人，女性30,349人），平均年龄为男性44.5岁，女性43.7岁。结果。除了最小的出生队列（1960-1969 年）外，在男性和女性的所有出生队列中，SUA 都随着年龄的增长而增加。 BMI 和饮酒量对 SUA 的纵向变化有正向贡献。然而，在控制 BMI 和饮酒量的模型中，SUA 也随着年龄的增长而增加。 SUA 存在出生队列效应；在大多数年龄段，男性年轻群体的 SUA 水平较高，女性年轻群体的 SUA 水平较低。结论。尽管饮酒和体重指数发生了变化，但男性和女性的 SUA 水平随着年龄的增长而增加。日本人口中的 SUA 水平存在出生队列效应。
Background. Serum uric acid (SUA) is related not only to an increased risk of gout, but also to an increased risk of cardiovascular diseases. However, real age-related changes in SUA remain unknown.Methods. Longitudinal population-based stud), of epidemiological follow-up data of SUA, body mass index (BMI), and alcohol intake was conducted at a health examination center between 1989 and 1998. The subjects were 80,506 Japanese office workers or their families (50.157 men and 30,349 women) with an average age of 44.5 years for the men and 43.7 years for the women.Results. SUA increased with age in all birth cohorts examined in men, and in women except for the youngest birth cohort (1960-1969). BMI and alcohol consumption positively contributed to the longitudinal changes of SUA. However, SUA also increased with age in the model controlled for BMI and alcohol consumption. There were birth cohort effects of SUA; at most ages, there were higher SUA levels in younger cohorts in men and lower SUA levels in younger cohorts in women, respectively.Conclusions. SUA levels in men and women increased with advancing age, despite changes in drinking and in the BMI. There are birth cohort effects for SUA levels in the Japanese population.