Spatial working memory activity of the caudate nucleus is sensitive to frame of reference
Spatial working memory activity of the caudate nucleus is sensitive to frame of reference
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DOI：
10.3758/cabn.3.2.133
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发表时间：
2003-06-01
影响因子：
2.9
通讯作者：
D'Esposito, Mark
中科院分区：
文献类型：
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作者：
Postle, Bradley R.;D'Esposito, Mark
我们使用事件相关的功能磁共振成像来检验这样的假设，即尾状核优先由使用自我中心定义的刺激的空间工作记忆任务招募，这些刺激可以转化为运动代码，而异中心定义的刺激则不能。我们的结果显示，在尾状核中，自我中心试验的延迟时期活动比异中心试验更大，并且壳核和外侧前运动皮层（PMC）的趋势相同。外侧 PMC 中自我中心试验的反应相关活动更大。我们认为，新纹状体可能与 PMC 相互作用，有助于建立预期运动代码（例如扫视或抓握的表示）所需的感觉运动转换。此外，PMC 可能会参与由探针刺激开始所促使的决策过程，该决策过程采用了这种预期的运动信息。该模型解释了运动分心会破坏空间工作记忆表现的经验证据。
We used event-related fMRI to test the hypothesis that the caudate nucleus is preferentially recruited by a spatial working memory task employing egocentrically defined stimuli, which are amenable to transformation into a motor code, as contrasted with allocentrically defined stimuli, which are not. Our results revealed greater delay-epoch activity in egocentric than in allocentric trials in the caudate nucleus and trends in the same direction in the putamen and the lateral premotor cortex (PMC). Response-related activity was greater for egocentric trials in the lateral PMC. We propose that the neostriatum, possibly interacting with the PMC, may contribute to the sensory-motor transformation necessary to establish a prospective motor code (e.g., the representation of a saccade or a grasp). In addition, the PMC may participate in decision-making processes, prompted by the onset of the probe stimulus, that employ this prospective motor information. This model accounts for the empirical evidence that motor distraction disrupts spatial working memory performance.