Leukemia mortality among workers at the Savannah River site
Leukemia mortality among workers at the Savannah River site
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DOI：
10.1093/aje/kwm176
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发表时间：
2007-11-01
影响因子：
5
通讯作者：
Wing, Steve
中科院分区：
文献类型：
--
作者：
Richardson, David B.;Wing, Steve
作者调查了萨凡纳河工地（南卡罗来纳州）工人中电离辐射与白血病死亡率之间的关系。1950年至1986年期间雇用的18 883名工人被跟踪到2002年，以确定死亡原因。来自外部来源和内部氚吸收的辐射剂量的估计数来自1999年的剂量测定记录。评价了白血病、白血病（不包括慢性淋巴细胞白血病）和髓性白血病的辐射剂量-死亡率趋势。在3年滞后假设下，白血病死亡率与辐射剂量呈正相关（超额相对率/10 mSv = 0.04，90%可信区间：-0.00，0.12）。除慢性淋巴细胞白血病（超额相对率/10 mSv = 0.08，90%置信区间：0.01，0.20）和髓系白血病（超额相对率/10 mSv = 0.12，90%置信区间：0.02，0.35）外，白血病的相关性更大。与男性相比，女性的剂量测定信息不完整;当分析仅限于男性时，每种死亡原因的估计关联在幅度和拟合优度上略有增加。3-15年前累积的暴露与白血病的相关性比更遥远的过去的暴露更强。本研究提供了萨凡纳河工地工人的辐射剂量和白血病死亡率之间正相关的证据。相关性的时间模式似乎与对受较高剂量率照射的人群进行的研究一致。
The authors investigated associations between ionizing radiation and leukemia mortality among workers at the Savannah River Site (South Carolina). A total of 18,883 workers hired between 1950 and 1986 were followed through 2002 to ascertain causes of death. Estimates of radiation doses from external sources and internal tritium uptakes were derived from dosimetry records through 1999. Radiation dose-mortality trends were evaluated for leukemia, leukemia excluding chronic lymphocytic leukemia, and myeloid leukemia. A positive association was observed between leukemia mortality and radiation dose under a 3-year lag assumption (excess relative rate/10 mSv = 0.04, 90% confidence interval: -0.00, 0.12). The association was of larger magnitude for leukemia excluding chronic lymphocytic leukemia (excess relative rate/10 mSv = 0.08, 90% confidence interval: 0.01, 0.20) and myeloid leukemia (excess relative rate/10 mSv = 0.12, 90% confidence interval: 0.02, 0.35). Compared with males, females had less complete dosimetry information; when analyses were restricted to males, the estimated association for each cause of death increased slightly in magnitude and goodness of fit. Exposures accrued 3-15 years prior were more strongly related to leukemia than exposures in the more distant past. This study provides evidence of positive associations between radiation dose and leukemia mortality among Savannah River Site workers. The temporal patterns of association appear consistent with those in studies of populations exposed at higher dose rates.