CHRONIC CUTANEOUS LUPUS-ERYTHEMATOSUS - CLINICAL, LABORATORY, THERAPEUTIC, AND PROGNOSTIC EXAMINATION OF 62 PATIENTS
CHRONIC CUTANEOUS LUPUS-ERYTHEMATOSUS - CLINICAL, LABORATORY, THERAPEUTIC, AND PROGNOSTIC EXAMINATION OF 62 PATIENTS
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DOI：
10.1001/archderm.118.6.412
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发表时间：
1982-01-01
影响因子：
--
通讯作者：
CALLEN, JP
中科院分区：
文献类型：
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作者：
CALLEN, JP
慢性盘状红斑狼疮（DLE）是一种常见病。观察62例经活检证实的活动性DLE患者，并分析其临床、实验室和治疗数据。五十六例患者的疾病仅限于皮肤，26例局限性和30例广泛（颈部以上和以下）。在随访检查时，32例患者存在活动性疾病，其中28例患者有广泛的DLE。6例患者有DLE作为系统性LE（SLE）的表现。4例DLE先于SLE发生。实验室异常在广泛性DLE患者中比局限性DLE患者更常见。对该系列治疗结果的分析证实了病灶内皮质类固醇和抗疟药的有益作用，并证明了局部或口服皮质类固醇的反应性相对较差。
Chronic discoid lupus erythematosus (DLE) is a common condition. Patients (62) with biopsy-proved, active DLE were observed, and their conditions were analyzed for clinical, laboratory and therapeutic data. Fifty-six patients had disease limited to the skin, 26 localized and 30 widespread (above and below the neck). At the time of follow-up examination, active disease was present in 32 patients, 28 of whom had widespread DLE. Six patients had DLE as a manifestation of systemic LE (SLE). In 4 patients, the DLE preceded the development of SLE. Laboratory abnormalities were substantially more common in patients with widespread DLE than in patients with localized DLE. An analysis of therapeutic results in this series confirmed the beneficial effects of intralesional corticosteroids and antimalarial agents, and demonstrated relatively poor responsiveness to topical or oral corticosteroids.