Revised map of the human progenitor hierarchy shows the origin of macrophages and dendritic cells in early lymphoid development
Revised map of the human progenitor hierarchy shows the origin of macrophages and dendritic cells in early lymphoid development
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DOI：
10.1038/ni.1889
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发表时间：
2010-07-01
影响因子：
30.5
通讯作者：
Dick, John E.
中科院分区：
文献类型：
--
作者：
Doulatov, Sergei;Notta, Faiyaz;Dick, John E.
造血的经典模型将淋巴和骨髓谱系的分离视为最早的命运决定。该模型在小鼠中的有效性受到质疑；然而，人们对人类祖先的谱系潜力知之甚少。在这里，我们通过克隆绘制新生儿脐带血和成人骨髓中七个祖细胞类别的发育潜力，对人类造血层次结构进行了全面分析。人类多淋巴祖细胞被鉴定为 CD34(+)CD38(-) 干细胞区室中 Thy-1(neg-lo)CD45RA(+) 细胞的独特群体，产生所有淋巴细胞类型以及单核细胞、巨噬细胞和树突状细胞，这表明这些骨髓谱系出现在早期淋巴谱系规范中。因此，与小鼠一样，人类造血并不遵循严格的骨髓-淋巴分离模型。
The classical model of hematopoiesis posits the segregation of lymphoid and myeloid lineages as the earliest fate decision. The validity of this model in the mouse has been questioned; however, little is known about the lineage potential of human progenitors. Here we provide a comprehensive analysis of the human hematopoietic hierarchy by clonally mapping the developmental potential of seven progenitor classes from neonatal cord blood and adult bone marrow. Human multilymphoid progenitors, identified as a distinct population of Thy-1(neg-lo)CD45RA(+) cells in the CD34(+)CD38(-) stem cell compartment, gave rise to all lymphoid cell types, as well as monocytes, macrophages and dendritic cells, which indicated that these myeloid lineages arise in early lymphoid lineage specification. Thus, as in the mouse, human hematopoiesis does not follow a rigid model of myeloid-lymphoid segregation.