[Clinical analysis of 16 cases of malignant head and neck melanoma].
[Clinical analysis of 16 cases of malignant head and neck melanoma].
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头颈部恶性黑色素瘤16例临床分析
DOI：
10.3950/jibiinkoka.104.859
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发表时间：
2001
期刊：
影响因子：
--
通讯作者：
Kichinobu Tomita
中科院分区：
文献类型：
--
作者：
M. Ryuto;Y. Higaki;Kichinobu Tomita
受试者为16例患者--5男11女，年龄46-82岁（平均61岁）--从1972年至1988年在我们诊所接受治疗的头颈部恶性黑色素瘤。组织学上，1例受试者为无黑色素型，15例为黑色素型。原发病灶包括鼻腔10例，鼻窦2例，牙龈2例，唇部1例，原发不明1例。他们接受或不接受多模式手术，放疗，化疗和免疫治疗。局部手术治疗12例，7个部位中6个局部复发。2年生存率为44%，5年生存率为22%。恶性头颈部黑色素瘤的预后很差，但由于术前对疾病扩散的决定和多模式治疗的引入，预后逐渐改善。
Subjects were 16 patients--5 men and 11 women aged 46-82 years (mean: 61 years)--with malignant melanoma of the head and neck treated at our clinic from 1972 to 1988. Histologically, 1 subjects was amelanotic and 15 melanotic type. Primary lesions were 10 involving the nasal cavity, 2 the paranasal sinus, 2 the gingiva, 1 the lip, and 1 primary unknown. They were treated with or without multimodal surgery, radiation, chemotherapy, and immunotherapy. Of 12 treated using local surgery, local recurrence was seen in 6 in 7 areas. Two-year survival was 44% and 5-year survival 22%. The prognosis of malignant head and neck melanoma is poor but has gradually improved due to preoperative decisions on disease spread and the introduction of multimodal therapy.