Retinoic acid treatment partially rescues failed septation in rats and in mice
Retinoic acid treatment partially rescues failed septation in rats and in mice
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DOI：
10.1152/ajplung.2000.278.5.l955
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发表时间：
2000-05-01
影响因子：
4.9
通讯作者：
Massaro, D
中科院分区：
文献类型：
--
作者：
Massaro, GD;Massaro, D
肺泡部分由未成熟肺的气体交换囊的细分（分隔）形成。分隔导致更小、更多的结构（肺泡），并且在哺乳动物（包括人类、大鼠和小鼠）中受到发育调节;如果未能在适当的时间发生，则不存在自发的事后分隔，也没有在未能发生后诱导分隔的方法。我们测量了肺体积，单个肺泡的体积，肺泡表面积和计算肺泡数在新生大鼠中，分隔已被封闭的治疗与糖皮质激素和成年皮肤紧绷的小鼠，有一个遗传性失败的分隔，我们测试的假设，治疗与全反式维甲酸诱导事后分隔。在两种失败的分隔模型中，因此在两个物种中，以及在未成熟和成年动物中，全反式维甲酸治疗诱导了事后分隔，这为早产儿提供了类似作用的可能性。
Pulmonary alveoli are formed in part by subdivision (septation) of the gas-exchange saccules of the immature lung. Septation results in smaller, more numerous structures (alveoli) and is developmentally regulated in mammals including humans, rats, and mice; if it fails to occur at the appropriate time, there is no spontaneous post hoc septation nor has there been a means of inducing septation after it has failed to occur. We measured lung volume, the volume of individual alveoli, and alveolar surface area and calculated alveolar number in neonatal rats in which septation had been blocked by treatment with a glucocorticosteroid hormone and in adult tight-skin mice that have a genetic failure of septation, We tested the hypothesis that treatment with all-trans retinoic acid induces post hoc septation. In both models of failed septation, hence in two species, and in immature and adult animals, treatment with all-trans retinoic acid induced post hoc septation, offering the possibility of a similar effect in premature infants.