Paracetamol and risk of ovarian cancer mortality in a prospective study of women in the USA
Paracetamol and risk of ovarian cancer mortality in a prospective study of women in the USA
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DOI：
10.1016/s0140-6736(05)60745-3
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发表时间：
1998-10-24
期刊：
影响因子：
168.9
通讯作者：
Thun, MJ
中科院分区：
文献类型：
--
作者：
Rodriguez, C;Henley, SJ;Thun, MJ
在该病例对照研究中，每周至少使用一次扑热息痛至少6个月的女性患卵巢癌的比值比为0.52，而从未使用过扑热息痛的女性患卵巢癌的风险最低，并且每天使用该药物超过10年的女性风险最低。提示的生物学机制包括对乙酰氨基酚的抗促性腺激素作用，如在喂食高水平对乙酰氨基酚的小鼠中观察到的生殖器萎缩所证明。
In that case-control study, the odds ratio of developing ovarian cancer among women who used paracetamol at least once a week for at least 6 months was 0.52 compared with never users, and the lowest risk was found for women who used the drug daily and for more than 10 years. Suggested biological mechanisms included an antigonadotropic effect of paracetamol as evidenced by genital atrophy observed in mice fed with high levels of paracetamol.