Altered connectivity within and between the default mode, central executive, and salience networks in obsessive-compulsive disorder
Altered connectivity within and between the default mode, central executive, and salience networks in obsessive-compulsive disorder
复制标题
强迫症中默认模式、中央执行网络和显着网络内部和之间的连接发生改变
DOI：
10.1016/j.jad.2017.07.041
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发表时间：
2017-12-01
影响因子：
6.6
通讯作者：
Zhu, Xiongzhao
中科院分区：
文献类型：
--
作者：
Fan, Jie;Zhong, Mingtian;Zhu, Xiongzhao
背景默认模式网络(DMN)、中央执行网络(CEN)和突显网络(SN)是人脑最重要的三个内在网络。最近的研究强调了三重网络模型的重要性，该模型说明了DMN、CEN和SN之间的相互作用在精神障碍的病理生理学中的作用。然而，以前对强迫症(OCD)的研究只探索了这些网络中改变的连接性，而忽略了它们之间的耦合。因此，本研究旨在填补这一研究空白。方法：采集35例强迫症患者和32例健康对照的静息状态功能磁共振成像(FMRI)数据。使用独立成分分析(ICA)提取DMN、CEN和SN的子网络。结果：强迫症患者在DMN、CEN和SN几个子系统内的功能连接性(FC)增加。此外，强迫症患者还表现出SN与前DMN(ADMN)以及SN与背侧CEN(DCEN)之间的功能相互作用异常，且SN与dCEN之间的相互作用与特质焦虑水平显著相关。局限性：缺乏对认知功能的评估是本研究的主要局限。结论：强迫症的神经生物学机制不仅涉及大脑核心内部大型网络之间的耦合受损，而且还涉及大规模神经认知网络之间的耦合，这反映了任务否定和任务积极加工模式之间的转换困难。
Background Default mode network (DMN), central executive network (CEN) and salience network (SN) are the three most important intrinsic networks of the human brain. Recent studies emphasized the importance of the "triple-network model" which illustrated the interactions within and between DMN, CEN and SN in the pathophysiology of psychiatric disorders. However, previous studies of obsessive-compulsive disorder (OCD) just explored the altered connectivity within these networks while neglected the coupling between them. Hence, the present study was designed to fill this research gap.Methods: Resting-state functional magnetic resonance imaging (fMRI) data from 35 OCD patients and 32 healthy controls (HCs) were acquired. Independent component analysis (ICA) was used to extract sub-networks of the DMN, CEN, and SN. Functional connectivity (FC) values within and between these networks were measured.Results: OCD patients had increased FC within several DMN, CEN, and SN subsystems. In addition, OCD patients demonstrated aberrant functional interactions between the SN and anterior DMN (aDMN) as well as between the SN and the dorsal CEN (dCEN), and the interaction between the SN and dCEN significantly correlated with trait anxiety level in the OCD group.Limitation: Lack of the assessments of cognitive functions is the main limitation of the present study.Conclusions: Not only impaired coupling within the brain core intrinsic large-scale networks, but also coupling between large-scale neurocognitive networks, which reflect the difficulties in switching between task-negative and task-positive processing modes are involved in the neurobiological mechanism of OCD.