CYP2D6 phenotype and the metabolism of nicotine and cotinine
CYP2D6 phenotype and the metabolism of nicotine and cotinine
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DOI：
10.1097/00008571-199606000-00006
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发表时间：
1996-06-01
期刊：
影响因子：
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通讯作者：
PerezStable, E
中科院分区：
文献类型：
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作者：
Benowitz, NL;Jacob, P;PerezStable, E
医学文献报道，CYP2D6 活性是尼古丁代谢的重要决定因素，CYP2D6 基因异常的人是尼古丁代谢不良的人。本研究的目的是评估 CYP2D6 在尼古丁代谢中的作用，具体来说，我们比较了右美沙芬（CYP2D6 活性探针）的 11 种弱代谢者和 33 种强代谢者中稳定同位素标记的尼古丁和可替宁的清除率，各组按性别、年龄和种族进行匹配，尼古丁和可替宁动力学在病例和 这些数据表明 CYP2D6 不是尼古丁或可替宁代谢的主要同工酶。
That CYP2D6 activity is an important determinant of nicotine metabolism and that people who have abnormal CYP2D6 genes are poor metabolizers of nicotine has been reported in the medical literature. The aim of this study was to assess the role of CYP2D6 in nicotine metabolism, Specifically, we compared the clearance of stable isotope-labelled nicotine and cotinine in 11 poor and 33 extensive metabolizers of dextromethorphan, a probe for CYP2D6 activity, The groups were matched by gender, age and ethnicity, Nicotine and cotinine kinetics were quite similar for cases and controls, These data suggest that CYP2D6 is nob a major isozyme for the metabolism of nicotine or cotinine.