Association between RECQL5 genetic polymorphisms and susceptibility to breast cancer
Association between RECQL5 genetic polymorphisms and susceptibility to breast cancer
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DOI：
10.1007/s13277-014-2528-2
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发表时间：
2014-12-01
期刊：
影响因子：
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通讯作者：
Wen, Ya-Yuan
中科院分区：
文献类型：
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作者：
He, Yu-Jun;Qiao, Zuo-Yi;Wen, Ya-Yuan
此前的研究表明，RECQL5基因多态性与人类癌症相关。然而，RECQL5基因多态性与乳腺癌的关联尚不清楚。在本研究中，我们调查了中国人群中 RECQL 基因多态性与乳腺癌之间的关联。我们为本研究选择了 RECQL5 基因的四个多态性（rs820186、rs820196、rs820200 和 rs4789223）。使用 TaqMan 方法对 510 名乳腺癌患者和 510 名年龄和性别匹配的非癌症对照患者进行了基因分型。我们发现RECQL5的rs820196和rs828200多态性与乳腺癌相关。对于 rs820196，CC 基因型（16.7 vs 9.4 %，P
Previous studies indicated that the RECQL5 gene polymorphism was associated with human cancers. However, the association of RECQL5 gene polymorphism with breast cancer remains unclear. In the present study, we investigated the association between polymorphisms of the RECQL gene and breast cancer in a Chinese population. We selected four polymorphisms of the RECQL5 gene (rs820186, rs820196, rs820200, and rs4789223) for the present study. The genotyping was performed using the TaqMan method in 510 patients with breast cancer and 510 age- and sex-matched non-cancer controls. We found that rs820196 and rs828200 polymorphisms of RECQL5 were associated with breast cancer. For rs820196, the CC genotype (16.7 vs 9.4 %, P