BMP/GDF-signalling interactions during synovial joint development
BMP/GDF-signalling interactions during synovial joint development
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DOI：
10.1007/s004410051272
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发表时间：
1999-04-01
影响因子：
3.6
通讯作者：
Archer, CW
中科院分区：
文献类型：
--
作者：
Francis-West, PH;Parish, J;Archer, CW
滑膜关节起源于最初的细胞凝聚，随后发展成不同的骨骼结构，由关节分开。骨形态发生蛋白（BMP）和生长分化因子（GDF）在骨骼发生（包括关节形成）过程中具有重要作用。关节的发育似乎依赖于相关BMP和GDF亚家族的差异表达/活性。Gdf-5在发育中的关节中表达，并且对于一些关节的形成是必需的。相反，最近的数据表明BMP家族的拮抗作用对于关节形成是至关重要的。在这里，我们审查的BMP信号可能被拮抗/修改的机制。我们还描述了表达的BMP-2和BMP-4连同两个BMP拮抗剂，chordin和noggin，在鸡关节发育。最后，我们讨论了可能的机制，如何联合形式和证据表明，联合是一个“信号中心”，可以协调相邻的骨骼结构的发展。
The synovial joint arises from an initial condensation of cells that subsequently develops into distinct skeletal structures, separated by the joint. Bone morphogenetic proteins (BMPs) and growth and differentiation factors (GDFs) have a fundamental role during skeletogenesis, including joint formation, Development of the joint appears to be dependent on the differential expression/activity of the related BMP and GDF subfamilies. Gdf-5 is expressed in the developing joints and is necessary for the formation of some joints, In contrast, recent data has shown that antagonism of the BMP family is crucial for joint formation. Here, we review mechanisms of how BMP signalling may be antagonised/modified. We also describe the expression of Bmp-2 and Bmp-4 together with two BMP antagonists, chordin and noggin, during chick joint development. Finally, we discuss possible mechanisms of how a joint forms and the evidence that the joint is a 'signalling centre' that may coordinate the development of adjacent skeletal structures.