PERSISTENT TRUNCUS ARTERIOSUS IN THE SPLOTCH MUTANT MOUSE
PERSISTENT TRUNCUS ARTERIOSUS IN THE SPLOTCH MUTANT MOUSE
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DOI：
10.1007/bf00305120
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发表时间：
1989-01-01
期刊：
影响因子：
--
通讯作者：
FRANZ, T
中科院分区：
文献类型：
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作者：
FRANZ, T
斑点突变小鼠显示出神经嵴衍生细胞群的缺陷。在Spotch突变等位基因Sp1H的纯合子中研究了动脉干的分隔和主动脉弓衍生血管的发育。结果表明，在纯合子突变胚胎中，动脉干的分隔不能正常进行，导致动脉干持续存在。永存动脉干开口通向右心室。经常观察到主动脉弓衍生的血管的变化。在突变体中，胸腺、甲状旁腺和后鳃体的发育也受到影响。这些结果提供了间接的证据，即小鼠主动脉弓和动脉干隔膜的细胞来源于神经嵴。建议将Spotch突变小鼠作为永存动脉干的动物模型。血管畸形的影响，这种突变体的妊娠中期死亡进行了讨论。
The Splotch mutant mouse shows defects in neural crest-derived cell populations. The septation of the truncus arteriosus and the development of the aortic arch-derived blood vessels was studied in homozygotes of the Splotch mutant allele Sp1H. It is shown that in homozygous mutant embryos, the septation of the truncus arteriosus does not proceed normally, resulting in persistent truncus arteriosus. The ostium of persistent truncus arteriosus opens to the right ventricle. Frequently, variations of the aortic arch-derived blood vessels are observed. The development of the thymus, the parathyroid and the ultimobranchial bodies are also variably affected in mutants. These results provide indirect evidence, that cells contributing to the aortic arches and the septum of the truncus arteriosus in mice are derived from the neural crest. The Splotch mutant mouse is proposed to be an animal model for persistent truncus arteriosus. The implications of the vascular malformations for the midgestational death of this mutant are discussed.