Hippocampal morphology and distinguishing late-onset from early-onset elderly depression
Hippocampal morphology and distinguishing late-onset from early-onset elderly depression
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DOI：
10.1176/appi.ajp.2007.07030506
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发表时间：
2008-02-01
影响因子：
17.7
通讯作者：
Kumar, Anand
中科院分区：
文献类型：
--
作者：
Ballmaier, Martina;Narr, Katherine L.;Kumar, Anand
目的：尽管有证据表明老年抑郁症患者海马异常，但尚不清楚这些变化是否具有区域特异性。本研究使用三维绘图技术来识别早发性和晚发性抑郁症的海马区域异常。方法：采用高分辨磁共振成像技术，对24例早发性抑郁症患者和22例晚发性抑郁症患者及34例对照组的海马形态进行比较。区域结构异常进行了比较距离，测量从同源海马表面点的中央核心，每个人的海马表面模型，groups.Results：海马体积不同抑郁症患者和比较科目，但不与早发性和迟发性抑郁症患者之间。然而，统计映射结果表明，区域表面收缩显着明显晚相比，早发性抑郁症的前下托和侧后方的CAI子字段在左半球。与对照受试者相比，在患者的前CA 1-CA 3子野和下托中观察到双侧显著的形状差异。当每个疾病组分别与对照受试者进行比较时，这些结果相似。海马表面收缩显着相关的记忆措施之间的晚，但不是早发性抑郁症患者或comparison subjects.Conclusions：更明显的区域体积赤字和他们的协会与记忆中的晚发性抑郁症可能表明，这些患者更有可能发展认知功能障碍随着时间的推移比个人早发性抑郁症。绘制区域海马异常及其认知相关性可能有助于指导确定风险特征和治疗策略的研究。
Objective: Despite evidence for hippocampal abnormalities in elderly depression, it is unknown whether these changes are regionally specific. This study used three-dimensional mapping techniques to identify regional hippocampal abnormalities in early- and late-onset depression. Neuropsychological correlates of hippocampal morphology were also investigated.Method: With high-resolution magnetic resonance imaging, hippocampal morphology was compared among elderly patients with early- (N=24) and late-onset (N=22) depression and comparison subjects (N=34). Regional structural abnormalities were identified by comparing distances, measured from homologous hippocampal surface points to the central core of each individual's hippocampal surface model, between groups.Results: Hippocampal volumes differed between depressed patients and comparison subjects but not between patients with early- and late-onset depression. However, statistical mapping results showed that regional surface contractions were significantly pronounced in late-compared to early-onset depression in the anterior of the subiculum and lateral posterior of the CAI subfield in the left hemisphere. Significant shape differences were observed bilaterally in anterior CA1-CA3 subfields and the subiculum in patients in relation to comparison subjects. These results were similar when each disease group was separately compared to comparison subjects. Hippocampal surface contractions significantly correlated with memory measures among late- but not early-onset depressed patients or comparison subjects.Conclusions: More pronounced regional volume deficits and their associations with memory in late-onset depression may suggest that these patients are more likely to develop cognitive impairment over time than individuals with early-onset depression. Mapping regional hippocampal abnormalities and their cognitive correlates may help guide research in defining risk profiles and treatment strategies.