Human interferon-inducible protein 10 is a potent inhibitor of angiogenesis in vivo.
Human interferon-inducible protein 10 is a potent inhibitor of angiogenesis in vivo.
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DOI：
10.1084/jem.182.1.155
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发表时间：
1995-07-01
期刊：
影响因子：
--
通讯作者：
Tosato G
中科院分区：
文献类型：
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作者：
Angiolillo AL;Sgadari C;Taub DD;Liao F;Farber JM;Maheshwari S;Kleinman HK;Reaman GH;Tosato G
人干扰素诱导蛋白10 （Human interferon-inducible protein 10, IP-10）是α趋化因子家族的一员，抑制骨髓集落形成，在体内具有抗肿瘤活性，是人单核细胞和T细胞的趋化剂，促进T细胞粘附内皮细胞。在这里，我们报道了IP-10是体内血管生成的有效抑制剂。IP-10对胸腺小鼠皮下注射碱性成纤维细胞生长因子诱导的Matrigel（由H. K. Kleinman制备）的新生血管有显著抑制作用。此外，IP-10在体外以剂量依赖的方式抑制内皮细胞向管状毛细血管结构的分化。在体外实验中，IP-10对内皮细胞的生长、附着和迁移没有影响。这些结果证明了IP-10的重要生物学特性，并提出了IP-10参与炎症和肿瘤发生过程中血管生成调节的可能性。
Human interferon-inducible protein 10 (IP-10), a member of the alpha chemokine family, inhibits bone marrow colony formation, has antitumor activity in vivo, is chemoattractant for human monocytes and T cells, and promotes T cell adhesion to endothelial cells. Here we report that IP-10 is a potent inhibitor of angiogenesis in vivo. IP-10 profoundly inhibited basic fibroblast growth factor-induced neovascularization of Matrigel (prepared by H. K. Kleinman) injected subcutaneously into athymic mice. In addition, IP-10, in a dose-dependent fashion, suppressed endothelial cell differentiation into tubular capillary structures in vitro. IP-10 had no effect on endothelial cell growth, attachment, and migration as assayed in vitro. These results document an important biological property of IP-10 and raise the possibility that IP-10 may participate in the regulation of angiogenesis during inflammation and tumorigenesis.