Schistosomes contain divergent ligand-gated ion channels with an atypical Cys-loop motif.
Schistosomes contain divergent ligand-gated ion channels with an atypical Cys-loop motif.
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血吸虫包含具有非典型Cys-loop基序的不同配体门控离子通道。
DOI：
10.17912/micropub.biology.000694
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发表时间：
2023
影响因子：
--
通讯作者：
Chan, John D
中科院分区：
文献类型：
--
作者：
Johnson, Hailey;VanHooreweghe, Mia;Satori, Jack A;Chan, John D
配体门控离子通道（LGIC）是神经肌肉功能的重要调节剂，使其成为有吸引力的抗寄生虫药物靶点。虽然蛔虫LGIC是几种驱虫药的目标，但扁虫LGIC的研究较少。染色体水平的基因组组装最近已被释放的血吸虫扁形虫物种，导致疾病血吸虫病。这些使我们能够全面预测一些LGIC，增加先前的注释。LGIC序列的分析揭示了一个分支的受体缺乏半胱氨酸在ependothelial Cys环区域的通道。由于这些非典型通道与哺乳动物LGIC不同，它们可能是治疗寄生扁形虫引起的疾病的有希望的靶点。
Ligand-gated ion channels (LGICs) are important regulators of neuromuscular function, making them attractive antiparasitic drug targets. While roundworm LGICs are targeted by several anthelmintic classes, flatworm LGICs are less studied. Chromosome-level genome assemblies have recently been released for Schistosoma flatworm species that cause the disease schistosomiasis. These have allowed us to comprehensively predict schistosome LGICs, adding to prior annotations. Analysis of LGIC sequences revealed a clade of receptors lacking cysteines at the eponymous Cys-loop region of the channel. Since these atypical channels are divergent from mammalian LGICs, they may be promising targets to treat diseases caused by parasitic flatworms.