Pet ownership, but not ACE inhibitor therapy, blunts home blood pressure responses to mental stress
Pet ownership, but not ACE inhibitor therapy, blunts home blood pressure responses to mental stress
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DOI：
10.1161/hyp.38.4.815
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发表时间：
2001-10-01
期刊：
影响因子：
8.3
通讯作者：
Izzo, JL
中科院分区：
文献类型：
--
作者：
Allen, K;Shykoff, BE;Izzo, JL
在本研究中，我们评估了非评价性社会支持干预（养宠物）在ACE抑制剂治疗前和治疗期间对精神压力血压反应的影响。48名高血压患者在家中和医生办公室参加了一项实验。参与者被随机分配到实验组，除了赖诺普利（20 mg/d）或对照组，只有赖诺普利（20 mg/d）的宠物所有权分配。在每个研究日，血压，心率和血浆肾素活性在基线和每个精神应激（连续减影和讲话）后记录。在药物治疗前，实验组和对照组对精神压力的平均反应在心率方面没有显著差异（94 [SD 6.8] vs 93 [6.8] bpm），收缩压（182 [8.0] vs 181 [8.3] mm Hg），舒张压（120 [6.6] vs 119 [7.9] min Hg）或血浆肾素活性（9.4 [0.59] vs 9.3 [0.57] ng.mL（-1）.h（-1））。赖诺普利治疗使两组患者的静息血压均降低约35/20 min Hg，但宠物主人对精神压力的反应明显低于仅接受赖诺普利治疗的患者（P
In the present study, we evaluated the effect of a nonevaluative social support intervention (pet ownership) on blood pressure response to mental stress before and during ACE inhibitor therapy. Forty-eight hypertensive individuals participated in an experiment at home and in the physician's office. Participants were randomized to an experimental group with assignment of pet ownership in addition to lisinopril (20 mg/d) or to a control group with only lisinopril (20 mg/d). On each study day, blood pressure, heart rate, and plasma renin activity were recorded at baseline and after each mental stressor (serial subtraction and speech). Before drug therapy, mean responses to mental stress did not differ significantly between experimental and control groups in heart rate (94 [SD 6.8] versus 93 [6.8] bpm), systolic blood pressure (182 [8.0] versus 181 [8.3] mm Hg), diastolic blood pressure (120 [6.6] versus 119 [7.9] min Hg), or plasma renin activity (9.4 [0.59] versus 9.3 [0.57] ng.mL(-1).h(-1)). Lisinopril therapy lowered resting blood pressure by approximate to 35/20 min Hg in both groups, but responses to mental stress were significantly lower among pet owners relative to those who only received lisinopril (P