STUDIES ON HISTIDINE-RICH POLYPEPTIDES FROM HUMAN PAROTID SALIVA
STUDIES ON HISTIDINE-RICH POLYPEPTIDES FROM HUMAN PAROTID SALIVA
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DOI：
10.1016/0003-9861(76)90455-0
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发表时间：
1976-01-01
影响因子：
3.9
通讯作者：
LONGTON, RW
中科院分区：
文献类型：
--
作者：
BAUM, BJ;BIRD, JL;LONGTON, RW
描述了从人腮腺唾液中分离富含组氨酸的多肽。这种多肽称为 HRP-1，含有 17% 的组氨酸。 HRP-1 是一种中性分子，是唾液中富含组氨酸的阳离子多肽的前体。体外唾液孵育的结果表明 HRP-1 的分解是酶介导的。降解的物种尺寸更小，电荷更多，并且组氨酸含量更高。唾液中的许多富含组氨酸的多肽可能并不都是单独的基因产物，而是通过蛋白水解降解相关。
The isolation of an histidine-rich polypeptide from human parotid saliva is described. This polypeptide, termed HRP-1, contains 17% histidine. HRP-1 is a neutral molecule and is a precursor of the cationic histidine-rich polypeptides found in saliva. Results of in vitro saliva incubations suggest that breakdown of HRP-1 is enzyme mediated. Degraded species are smaller in size, more cationic in charge, and higher in histidine content. The many histidine-rich polypeptides in saliva probably are not all individual gene products and are related by a proteolytic degradation.