BODY-MASS INDEX - AN INDEPENDENT PREDICTOR OF CATARACT
BODY-MASS INDEX - AN INDEPENDENT PREDICTOR OF CATARACT
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DOI：
10.1001/archopht.1995.01100090057023
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发表时间：
1995-09-01
影响因子：
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通讯作者：
HENNEKENS, CH
中科院分区：
文献类型：
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作者：
GLYNN, RJ;CHRISTEN, WG;HENNEKENS, CH
目的：探讨体重指数是否是白内障的独立预测因子。(Body质量指数是一种标准化的测量方法，定义为体重（千克）除以身高（米）的平方。设计图：前瞻性队列研究，随访5年。参与者：共有17764名美国男性医生参加了医生健康研究，年龄在40至84岁之间，基线时无白内障、心肌梗死、中风和癌症，并报告了有关体重指数和其他白内障风险因素的完整信息。主要结果测量：事件白内障，定义为一个自我报告，确认的医疗记录审查，首次诊断后，随机化，年龄相关的起源，并负责最佳矫正视力下降到20/30或worsen.Results：事件白内障发生在随访期间在370名参与者。在调整了潜在混杂变量的比例风险模型中，体重指数与白内障风险有很强的分级关系。相对于体重指数小于22的患者，体重指数22至小于25、25至小于27.8和27.8或更高的相对风险（95%置信区间）分别为1.54（1.04至2.27）、1.46（0.98至2.20）和2.10（1.35至3.25）。相对于任何给定的体重指数水平，高2个单位的体重指数水平预测白内障风险增加12%（95%置信区间，5%至19%）。较高的身体质量指数是特别密切相关的风险后囊下和核巩膜白内障，也显着相关的风险白内障extraction.Conclusions：在一项前瞻性队列研究的健康男性，较高的身体质量指数，一个潜在的可修改的危险因素，是一个决定性的白内障。最瘦的男性患病率最低，这与限制能量摄入减缓白内障发展的实验证据一致。虽然确切的机制尚不清楚，但体重指数对白内障发生的影响显然与其他风险因素无关，包括年龄，吸烟和诊断的糖尿病。
Objective: To examine whether body mass index is an independent predictor of cataract. (Body mass index is a standardized measure defined as weight in kilograms divided by the square of the height in meters.)Design: Prospective cohort study, with 5 years of follow-up.Participants: A total of 17 764 US male physicians participating in the Physicians' Health Study, aged 40 to 84 years, who were free of cataract, myocardial infarction, stroke, and cancer at baseline and reported complete information about body mass index and other cataract risk factors.Main Outcome Measure: Incident cataract, defined as a self-report, confirmed by medical record review, first diagnosed after randomization, age-related in origin, and responsible for a decrease in best corrected visual acuity to 20/30 or worse.Results: Incident cataract occurred during follow-up in 370 participants. In proportional hazards models that adjusted for potential confounding variables, body mass index had a strong, graded relationship with risk of cataract. Relative to those with body mass index less than 22, relative risks (95% confidence intervals) associated with body mass index of 22 to less than 25, 25 to less than 27.8, and 27.8 or more were 1.54 (1.04 to 2.27), 1.46 (0.98 to 2.20), and 2.10 (1.35 to 3.25),respectively. Relative to any given level of body mass index, a 2-unit higher level predicted a 12% increase in risk of cataract (95% confidence interval, 5% to 19%). Higher body mass index was especially strongly related to risk of posterior subcapsular and nuclear sclerotic cataracts and was also significantly related to risk of cataract extraction.Conclusions: In a prospective cohort study of apparently healthy men, higher body mass index, a potentially modifiable risk factor, was a determinant of cataract. The leanest men had the lowest rates, consistent with experimental evidence that restriction of energy intake slows development of cataract. Although precise mechanisms are unclear, the effect of body mass index on cataractogenesis is apparently independent of other risk factors, including age, smoking, and diagnosed diabetes.