Immunohistochemical localization of fibroblast growth factor-1 (FGF-1), FGF-2 and fibroblast growth factor receptor-1 (FGFR-1) in pleomorphic adenoma of the salivary glands.
Immunohistochemical localization of fibroblast growth factor-1 (FGF-1), FGF-2 and fibroblast growth factor receptor-1 (FGFR-1) in pleomorphic adenoma of the salivary glands.
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唾液腺多形性腺瘤中成纤维细胞生长因子-1 (FGF-1)、FGF-2 和成纤维细胞生长因子受体-1 (FGFR-1) 的免疫组织化学定位。
DOI：
10.1111/j.1600-0714.1997.tb00004.x
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Takada,K
中科院分区：
文献类型：
--
作者：
Myoken,Y;Myoken,Y;Okamoto,T;Sato,JD;Kan,M;McKeehan,WL;Fujihara,M;Takada,K
成纤维细胞生长因子-1（FGF-1）和FGF-2是肝素结合性多肽，是肿瘤细胞的强效有丝分裂原。在这项研究中，成纤维细胞生长因子-1（FGF-1），FGF-2和成纤维细胞生长因子受体-1（FGfR-1）在10例多形性腺瘤的唾液腺通过使用特异性单克隆抗体进行化学分析。组织病理学分型为管状、实性、粘液样和软骨样。FGF-1和FGF-2在所有组织学类型的肿瘤细胞中均被化学鉴定。此外，在管状型肿瘤细胞的基底膜中也发现了免疫反应性FGF-2。相反。FGfR-1阳性肿瘤细胞基本上局限于肿瘤的管状和实体区域。粘液样和软骨样区域中的肿瘤细胞为FGfR-1免疫阴性。这些结果表明，FGF及其受体的共表达似乎与管状和实体区域中肿瘤细胞的增殖活性相关，而FGF受体表达的缺失可能与肿瘤细胞分化为粘液样和软骨样组织类型相关。
Fibroblast growth faclor‐1 (FGF‐l) and FGF‐2 are heparin‐binding polypeplides that are potent mitogens for neoplastic cells. In this study, fibroblast growth factor‐1 (FGF‐l), FGF‐2, and fibroblast growth factor receptor‐1 (FGfR‐1) were immunohistochemically analyzed in 10 patients with pleomorphic adenoma of the salivary gland by using specific monoclonal antibodies. The tumor tissues were histopathologically classified as: tubular, solid, myxoid or chondroid. Both FGF‐1 and FGF‐2 were immunohistochemically identified in the tumor cells of all histological types. In addition, immunoreactive FGF‐2 was also found in the basement membrane of tubular type tumor cells. Conversely. FGfR‐1‐positive tumor cells were essentially confined to the tubular and solid areas of tumors. Tumor cells in the myxoid and chondroid areas were FGfR‐1 immunonegative. These results suggest that the co‐expression of FGF and its receptor appears to be related to the proliferative activity of tumor cells in the tubular and solid areas, whereas loss of FGF receptor expression may be associated with the differentiation of tumor cells into myxoid and chondroid tissue types.