Different effects of high molecular weight sodium hyaluronate and NSAID on the progression of the cartilage degeneration in rabbit OA model
Different effects of high molecular weight sodium hyaluronate and NSAID on the progression of the cartilage degeneration in rabbit OA model
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DOI：
10.1016/j.joca.2006.11.001
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发表时间：
2007-05-01
影响因子：
7
通讯作者：
Saito, K.
中科院分区：
文献类型：
--
作者：
Mihara, M.;Higo, S.;Saito, K.
目的：本研究观察了非甾体类抗炎药（NSAID）和透明质酸钠（HA）关节腔内注射对兔膝骨关节炎（OA）软骨退变的影响。从盲肠切除术当天开始，以4 mg/kg的剂量每天一次，持续14天。使用Suvenyl（R）（SVE）作为高分子量HA，从手术当天起每3天关节内注射到受伤的膝关节中。术后14 d，用不电容测试仪测定疼痛，用肉眼观察和组织病理学检查评价软骨损伤情况。在其他三个组中，后爪重量分布的减少被抑制，证明了镇痛作用。在第14天，对照组的软骨中可见明显的损伤和软骨变性的组织病理学发现。SVE组软骨损伤面积减少，软骨退变减轻。相反，在LOX组中，与对照组相比，软骨退变加重。SVE可逆转LOX诱导的软骨退变。结论：我们的数据表明，从早期开始用高分子量HA治疗是强烈推荐的，以保护软骨结构。(C)2006年国际骨关节炎研究学会。由爱思唯尔有限公司出版。保留所有权利。
Objective: We examined the effects of nonsteroidal anti-inflammatory drug (NSAID) and intra-articular injections of sodium hyaluronate (HA) on cartilage degeneration in rabbit knee osteoarthritis (OA) model induced by partial meniscectomy.Methods: Loxoprofen sodium (LOX) was used as the NSAID, administered p.o. once daily for 14 days at a dose of 4 mg/kg, starting from the day of meniscectomy. Suvenyl(R) (SVE) was used as the high molecular weight HA, injected intra-articularly into injured knee every 3 days from the day of surgery. The effect on pain was assessed by an Incapacitance Tester, and the damage of cartilage was evaluated by visual assessment and histopathology at 14 days after the surgery.Results: Hind paw weight bearing on the injured paw decreased time-dependently in the control group. In other three groups, the decrease of hind paw weight distribution was suppressed, demonstrating an analgesic effect. Visible damage and histopathological findings of cartilage degeneration were evident in the cartilages of the control group at day 14. In the SVE group, the damaged cartilage area decreased and cartilage degeneration was ameliorated. In contrast, in the LOX group, the cartilage degeneration was augmented compared with the control group. And, this exacerbated cartilage degeneration induced by LOX was reversed by the concomitant use of SVE.Conclusion: Our data show that the treatment with high molecular weight HA from earlier stage is strongly recommended to preserve the structure of cartilage. (C) 2006 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.