Transition-Metal-Free Conversion of Trifluoropropanamides into Cyanoformamides through C-CF3 Bond Cleavage and Nitrogenation.
Transition-Metal-Free Conversion of Trifluoropropanamides into Cyanoformamides through C-CF3 Bond Cleavage and Nitrogenation.
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DOI：
10.1021/acs.joc.7b00626
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发表时间：
2017-05
期刊：
影响因子：
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通讯作者：
F. Wang;Zhang Tao;H. Tu;Xing‐Guo Zhang
中科院分区：
文献类型：
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作者：
F. Wang;Zhang Tao;H. Tu;Xing‐Guo Zhang
描述了一种新的无过渡金属三氟丙酰胺转化为氰基甲酰胺的方法，通过一系列 C-CF3 键断裂和氮化，使用亚硝酸叔丁酯作为氮源。该方法具有直接脱三氟甲基化、底物适用范围广、选择性控制优良等特点，为C-CF3σ键断裂构建腈基提供了一条新的捷径。
A new transition-metal-free transformation of trifluoropropanamides into cyanoformamides through a sequence of C-CF3 bond cleavage and nitrogenation using tert-butyl nitrite as the nitrogen source is described. The method features direct detrifluoromethylation, broad substrate scopes, and excellent selectivity control, representing a new shortcut for constructing the nitrile group involving C-CF3 σ-bond cleavage.