Data resource profile: cardiovascular disease research using linked bespoke studies and electronic health records (CALIBER).
Data resource profile: cardiovascular disease research using linked bespoke studies and electronic health records (CALIBER).
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DOI：
10.1093/ije/dys188
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发表时间：
2012-12
影响因子：
7.7
通讯作者：
Hemingway H
中科院分区：
文献类型：
--
作者：
Denaxas SC;George J;Herrett E;Shah AD;Kalra D;Hingorani AD;Kivimaki M;Timmis AD;Smeeth L;Hemingway H
使用链接的定制研究和电子健康记录 (CALIBRE) 进行心血管疾病 (CVD) 研究的目标是提供证据，为 CVD 的不同转化阶段（从发现、试验评估到实施）提供医疗保健和公共卫生政策，其中与电子健康记录的链接提供了新的科学机会。 CALIBRE 计划的初步方法特点如下： (i) 多个电子健康记录来源的关联：示例包括来自临床实践研究数据链的纵向初级保健数据、国家急性冠状动脉综合征登记（心肌缺血国家审计项目）、来自医院发作统计的住院和手术数据以及来自国家统计办公室的特定原因死亡率和社会剥夺数据之间的关联。目前的队列分析涉及 100 万人，其中包括最初健康的人群和疾病登记处的约 105 名患者。 (ii) 将定制的研究者主导的队列研究（例如英国生物银行）与登记数据（例如心肌缺血国家审计项目）联系起来，提供确定、验证和分型疾病的新方法。 (iii) 通用数据模型，其中通过定义和管理关于风险因素、CVD 和非心血管合并症的超过 300 个变量（分类、连续、事件）的元数据，使常规电子健康记录数据做好研究准备并可共享。 (iv) 透明度：所有 CALIBRE 研究都有在公共领域注册的分析协议，并且数据可供使用（安全港模型），但须经批准。欲了解更多信息，请发送电子邮件至 s.denaxas@ucl.ac.uk
The goal of cardiovascular disease (CVD) research using linked bespoke studies and electronic health records (CALIBER) is to provide evidence to inform health care and public health policy for CVDs across different stages of translation, from discovery, through evaluation in trials to implementation, where linkages to electronic health records provide new scientific opportunities. The initial approach of the CALIBER programme is characterized as follows: (i) Linkages of multiple electronic heath record sources: examples include linkages between the longitudinal primary care data from the Clinical Practice Research Datalink, the national registry of acute coronary syndromes (Myocardial Ischaemia National Audit Project), hospitalization and procedure data from Hospital Episode Statistics and cause-specific mortality and social deprivation data from the Office of National Statistics. Current cohort analyses involve a million people in initially healthy populations and disease registries with ∼105 patients. (ii) Linkages of bespoke investigator-led cohort studies (e.g. UK Biobank) to registry data (e.g. Myocardial Ischaemia National Audit Project), providing new means of ascertaining, validating and phenotyping disease. (iii) A common data model in which routine electronic health record data are made research ready, and sharable, by defining and curating with meta-data >300 variables (categorical, continuous, event) on risk factors, CVDs and non-cardiovascular comorbidities. (iv) Transparency: all CALIBER studies have an analytic protocol registered in the public domain, and data are available (safe haven model) for use subject to approvals. For more information, e-mail s.denaxas@ucl.ac.uk