Monitoring Pc 4 photodynamic therapy in clinical trials of cutaneous T-cell lymphoma using noninvasive spectroscopy.
Monitoring Pc 4 photodynamic therapy in clinical trials of cutaneous T-cell lymphoma using noninvasive spectroscopy.
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使用无创光谱学监测皮肤 T 细胞淋巴瘤临床试验中的 Pc 4 光动力疗法。
DOI：
10.1117/1.2939068
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发表时间：
2008
影响因子：
3.5
通讯作者：
Foster,ThomasH
中科院分区：
文献类型：
--
作者：
Lee,TammyK;Baron,ElmaD;Foster,ThomasH
酞菁硅pc4光动力疗法（pc4 - pdt）已成为一种潜在有效的治疗皮肤t细胞淋巴瘤（CTCL）的方法。PDT之前、期间和之后的非侵入性反射和荧光光谱可以提供有用的剂量指标，并使治疗能够针对个别病变进行定制。我们提出了一种便携式床边光谱系统的设计和实现，用于CTCL的pc4 - pdt的初步临床试验。在整个PDT治疗过程中获得了早期CTCL患者的反射光谱和荧光光谱。初步患者数据显示，pc4对组织吸收有显著影响，轻度pc4光漂白，病变内部和病变之间的pc4异质性。
Silicon phthalocyanine Pc 4 photodynamic therapy (Pc 4-PDT) has emerged as a potentially effective treatment for cutaneous T-cell lymphoma (CTCL). Noninvasive reflectance and fluorescence spectroscopy before, during, and after PDT may provide useful dose metrics and enable therapy to be tailored to individual lesions. We present the design and implementation of a portable bedside spectroscopy system for initial clinical trials of Pc 4-PDT of CTCL. Reflectance and fluorescence spectra were obtained from an early stage CTCL patient throughout the course of the PDT treatment. Preliminary patient data show a significant effect of Pc 4 on the tissue absorption, modest Pc 4 photobleaching, and heterogeneity of Pc 4 within and between the lesions.