Spectrally resolved bioluminescence optical tomography
Spectrally resolved bioluminescence optical tomography
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DOI：
10.1364/ol.31.000365
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发表时间：
2006-02-01
期刊：
影响因子：
3.6
通讯作者：
Patterson, MS
中科院分区：
文献类型：
--
作者：
Dehghani, H;Davis, SC;Patterson, MS
光谱分辨生物发光光学层析成像是一种利用内部生物发光源的多波长发射数据恢复体积内荧光素酶活性图像的方法。与非光谱分辨的基于强度的生物发光断层扫描相关的独特性的潜在问题被强调。利用模拟组织体模的模拟多波长数据和真实多波长数据作为输入，给出了重建的生物发光图像。内部生物发光的位置以1 mm的精度获得。此外，重建光源的幅度与实际的生物发光强度成正比。(C)2006年美国光学学会。
Spectrally resolved bioluminescence optical tomography is an approach to recover images of luciferase activity within a volume using multiwavelength emission data from internal bioluminescence sources. The underlying problem of uniqueness associated with nonspectrally resolved intensity-based bioluminescence tomography is highlighted. Reconstructed images of bioluminescence are presented by using as input both simulated and real multiwavelength data from a tissue-simulating phantom. The location of the internal bioluminescence is obtained with 1 mm accuracy. Further, the amplitude of the reconstructed source is proportional to the actual bioluminescence intensity. (c) 2006 Optical Society of America.