Differentiation Between Luminal-A and Luminal-B Breast Cancer Using Intravoxel Incoherent Motion and Dynamic Contrast-Enhanced Magnetic Resonance Imaging
Differentiation Between Luminal-A and Luminal-B Breast Cancer Using Intravoxel Incoherent Motion and Dynamic Contrast-Enhanced Magnetic Resonance Imaging
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DOI：
10.1016/j.acra.2017.06.016
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发表时间：
2017-12-01
影响因子：
4.8
通讯作者：
Gabata, Toshifumi
中科院分区：
文献类型：
--
作者：
Kawashima, Hiroko;Miyati, Tosiaki;Gabata, Toshifumi
基本原理和目标：本研究旨在探讨体素内非相干运动（IVIM）和动态对比增强（DCE）磁共振成像（MRI）能否区分B腔和A腔乳腺癌。材料和方法：采用3.0 T MRI扫描仪，对134例137例经病理证实的腔型浸润性乳腺癌患者的IVIM和DCE MRI进行双指数分析。管腔型乳腺癌分为管腔B型乳腺癌（LBBC，Ki-67 >= 14%）或管腔A型乳腺癌（LABC，Ki-67 < 14%）。计算IVIM（纯扩散系数[D]、灌注相关扩散系数[D*]和分数[f]）和DCE MRI（初始增强百分比和信号增强比[SER]）的定量参数。表观扩散系数（ADC）也使用单指数拟合计算。结果：LBBC的D值和ADC值均显著低于LABC（P = 0.028，P = 0.037）。LBBC的SER显著高于LABC（P = 0.004）。单变量分析显示，显著降低的D（
Rationale and Objectives: The study aimed to investigate whether intravoxel incoherent motion (IVIM) and dynamic contrast enhanced (DCE) magnetic resonance imaging (MRI) can differentiate luminal-B from luminal-A breast cancerMaterials and Methods: Biexponential analyses of IVIM and DCE MRI were performed using a 3.0-T MRI scanner, involving 134 patients with 137 pathologically confirmed luminal-type invasive breast cancers. Luminal-type breast cancer was categorized as luminal-B breast cancer (LBBC, Ki-67 >= 14%) or luminal-A breast cancer (LABC, Ki-67 < 14%). Quantitative parameters from IVIM (pure diffusion coefficient [D], perfusion-related diffusion coefficient [D*], and fraction [f]) and DCE MRI (initial percentage of enhancement and signal enhancement ratio [SER]) were calculated. The apparent diffusion coefficient (ADC) was also calculated using monoexponential fitting. We correlated these data with the Ki-67 status.Results: The D and ADC values of LBBC were significantly lower than those of LABC (P = 0.028, P = 0.037). The SER of LBBC was significantly higher than that of LABC (P = 0.004). A univariate analysis showed that a significantly lower D (