A genome-wide quantitative trait locus (QTL) linkage scan of NEO personality factors in Latino families segregating bipolar disorder.
A genome-wide quantitative trait locus (QTL) linkage scan of NEO personality factors in Latino families segregating bipolar disorder.
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DOI：
10.1002/ajmg.b.32551
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发表时间：
2017-10
期刊：
影响因子：
--
通讯作者：
Escamilla M
中科院分区：
文献类型：
--
作者：
Lee BD;Gonzalez S;Villa E;Camarillo C;Rodriguez M;Yao Y;Guo W;Flores D;Jerez A;Raventos H;Ontiveros A;Nicolini H;Escamilla M
Personality traits have been suggested as potential endophenotypes for Bipolar Disorder (BP), as they can be quantitatively measured and show correlations with BP. The present study utilized data from 2745 individuals from 686 extended pedigrees originally ascertained for having multiplex cases of BP (963 cases of BPI or schizoaffective BP). Subjects were assessed with the NEO Personality Inventory, Revised (NEO PI-R) and genotyped using the Illumina HumanLinkage-24 Bead Chip, with an average genetic coverage of 0.67 cM. Two point linkage scores were calculated for each trait as a quantitative variable using SOLAR (Sequential Oligogenic Linkage Analysis Routines). Suggestive evidence for linkage was found for neuroticism at 1q32.1 (LOD=2.52), 6q23.3 (2.32), 16p12 (2.79), extraversion at 4p15.3 (2.33), agreeableness at 4q31.1 (2.37), 5q34 (2.80), 7q31.1 (2.56), 16q22 (2.52), and conscientiousness at 4q31.1 (2.50). Each of the above traits have been shown to be correlated with the broad BP phenotype in this same sample. In addition, for the trait of openness, we found significant evidence of linkage to chromosome 3p24.3 (rs336610, LOD=4.75) and suggestive evidence at 1q43 (2.74), 3p26 (2.71), 5q35.1 (3.03), 11q14.3 (2.61), 11q21 (2.30), and 19q13.1 (2.52). These findings support previous linkage findings of the openness trait to chromosome 19q13 and the agreeableness trait to 4q31 and identify a number of new loci for personality endophenotypes related to bipolar disorder.
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DOI：
10.1176/appi.ajp.2010.10091340
发表时间：
2011-03
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Gershon ES;Alliey-Rodriguez N;Liu C
通讯作者：
Liu C
影响因子：
12.3
作者：
Doherty JL;Owen MJ
通讯作者：
Owen MJ
DOI：
10.1523/jneurosci.1436-12.2012
发表时间：
2012-08-15
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Dhingra A;Ramakrishnan H;Neinstein A;Fina ME;Xu Y;Li J;Chung DC;Lyubarsky A;Vardi N
通讯作者：
Vardi N
影响因子：
5
作者：
BERGEMAN, CS;CHIPUER, HM;MCCRAE, RR
通讯作者：
MCCRAE, RR
影响因子：
7.6
作者：
Jang, KL;McCrae, RR;Livesley, WJ
通讯作者：
Livesley, WJ