Mouse models for studying prostate cancer bone metastasis
Mouse models for studying prostate cancer bone metastasis
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DOI：
10.1038/bonekey.2016.4
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发表时间：
2016-02-17
期刊：
影响因子：
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通讯作者：
Shiozawa, Yusuke
中科院分区：
文献类型：
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作者：
Dai, Jinlu;Hensel, Janine;Shiozawa, Yusuke
一旦肿瘤细胞转移到骨骼，前列腺癌患者的预后通常很差。然而，由于缺乏相关的动物模型，涉及骨转移的机制仍然难以捉摸。在这篇手稿中，我们描述了目前用于研究前列腺癌骨转移的异种移植小鼠模型的逐步方案。不同的肿瘤接种途径(骨内、心内、静脉和原位)对于探索骨转移的生物学是有用的。
Once tumor cells metastasize to the bone, the prognosis for prostate cancer patients is generally very poor. The mechanisms involved in bone metastasis, however, remain elusive, because of lack of relevant animal models. In this manuscript, we describe step-by-step protocols for the xenograft mouse models that are currently used for studying prostate cancer bone metastasis. The different routes of tumor inoculation (intraosseous, intracardiac, intravenous and orthotopic) presented are useful for exploring the biology of bone metastasis.