Immune mechanisms in chlamydial eye infection: cellular immune responses in chronic and acute disease.
Immune mechanisms in chlamydial eye infection: cellular immune responses in chronic and acute disease.
复制标题
衣原体眼部感染的免疫机制：慢性和急性疾病中的细胞免疫反应。
DOI：
10.1093/infdis/150.5.745
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
Taylor,HR
中科院分区：
文献类型：
--
作者：
Young,E;Taylor,HR
目前的研究详细描述了急性和慢性感染的猴子对沙眼衣原体抗原的细胞介导的免疫应答。检测了三组动物（感染前免疫、感染前未免疫和慢性感染）的外周血单核白细胞（PBML）对C.沙眼抗原体外检测。只有那些在急性眼部感染前已经全身免疫的动物才有显著的反应。从无反应的动物与D-组织相容性反应的动物的T细胞的巨噬细胞共培养表明，在无反应的动物中，呈递抗原的能力不受影响。这些研究还表明，在培养前从PBML中去除抑制性T细胞导致慢性感染组的增殖增加，并表明在慢性眼病中观察到的无反应性可能是由抑制性T细胞介导的。
The current studies detail cell-mediated immune responses toChlamydia trachomatisantigen in both acute and chronically infected monkeys. Peripheral blood mononuclear leukocytes (PBMLs) from three groups of animals (immunized before infection, not immunized before infection, and chronically infected) were tested for the capacity to proliferate in response toC. trachomatisantigen in vitro. Only those animals that had been systemically immunized before acute ocular infection responded significantly. Coculturing macrophages from nonresponding animals with T cells from D-histocompatible responding animals showed that the ability to present antigen was unaffected in nonresponding animals. These studies also demonstrated that removal of suppressor T cells from PBMLs before culture resulted in increased proliferation in the chronically infected group and suggested that the nonresponsiveness seen in chronic ocular disease may be mediated by suppressor T cells.