[Epidemiology and clinical manifestations of Adamantiades-Behcet disease in Germany -- current pathogenetic concepts and therapeutic possibilities].
[Epidemiology and clinical manifestations of Adamantiades-Behcet disease in Germany -- current pathogenetic concepts and therapeutic possibilities].
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DOI：
10.1111/j.1610-0387.2006.05841.x
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发表时间：
2006-01-01
期刊：
影响因子：
--
通讯作者：
Zouboulis, Christos C
中科院分区：
文献类型：
--
作者：
Altenburg, Andreas;Papoutsis, Nestor;Zouboulis, Christos C
科斯的希波克拉底（Hippocrates of Kos，公元前460-377年）在他的第三本书《Epidimion》中描述了一种疾病，其症状与Adamantiades-Behçet病（ABD）的主要症状相当：“许多患者的口腔出现了口疮性溃疡。有许多化脓性生殖器溃疡和疖，包括外部和内部以及腹股沟。有一种慢性的、疼痛的眼部水状炎症，以及眼睑内外的生长，这损害了许多患者的视力。(...)在许多患者中也有较大的疮和大疱疹病变。1930年，希腊眼科医生Benediktos Adamantiades（1875-1965）在一次演讲中描述了一名18岁患者的发现，首次将眼部症状、口腔口疮和生殖器溃疡归类为单一临床实体的症状。他后来将血管受累作为第四个主要症状，并在一篇综述文章中通过描述其眼部、粘膜皮肤和全身形式提出了该疾病的第一个分类[1]。根据阿达曼提德斯的说法，主要症状是前房积脓，出现的时间不一，造成或多或少的永久性损伤，最终导致失明。土耳其皮肤科医生Huliosi Behçet（1889-1948）于1937年首次描述了影响口腔、生殖器和眼睛的复发性病变患者，并增加了一系列症状，包括牙周炎、颌骨囊肿、痤疮样皮肤变化、结节性红斑以及关节痛。贝塞特对这种疾病的深入研究和他对这种疾病自主性的信念最终使这一令人困惑的临床图景引起了科学界的注意。
In his third book of “Epidimion” Hippocrates of Kos (460–377 BC) described a disease with symptoms comparable to the cardinal symptoms of Adamantiades-Behçet disease (ABD):“Many patients had aphthous ulcerations in the mouth. There were numerous purulent genital ulcers, as well as furuncles, which were external and internal, as well as in the groins. There was a watery inflammation of the eye that was chronic and painful as well as growths on the eyelids–external and internal–which impaired eyesight in many patients.(…) There were also larger ecthymata and large herpetic lesions in many patients.“In 1930 Benediktos Adamantiades (1875–1965), a Greek ophthalmologist, presented a lecture describing findings in an 18-year-old patient, for the first time grouping ocular symptoms, oral aphthae, and genital ulcers together as symptoms of a single clinical entity. He later added vascular involvement as a fourth cardinal symptom and in a review article presented the first classification of the disease by describing its ocular, mucocutaneous, and systemic forms [1]. The chief symptom, which according to Adamantiades was hypopyon, appears at various intervals, causing more or less lasting permanent damage and ultimately resulting in blindness. Hulûsi Behçet (1889–1948), a Turkish dermatologist, first described in 1937 patients with recurrent lesions affecting the mouth, genitals, and eyes, adding a catalogue of symptoms including periodontitis, jaw cysts, acneiform skin changes, and erythema nodosum as well as arthralgia. Behçet’s intense work on the disease and his conviction about its autonomous character finally brought this puzzling clinical picture to the attention of the scientific community.