Proteomic profiles of melanoma cell-derived exosomes in plasma: discovery of potential biomarkers of melanoma progression.
Proteomic profiles of melanoma cell-derived exosomes in plasma: discovery of potential biomarkers of melanoma progression.
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DOI：
10.1097/cmr.0000000000000762
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发表时间：
2021-10-01
影响因子：
2.2
通讯作者：
Whiteside TL
中科院分区：
文献类型：
--
作者：
Mondal SK;Whiteside TL
包括循环肿瘤细胞（CTC）、循环肿瘤DNA（ctDNA）和/或肿瘤来源的外来体（TEX）的癌症液体活检作为早期检测、非侵入性监测对治疗的反应和预测患者存活的新方法而出现。TEX是液体活检的关键成分，因为它们在蛋白质组和遗传内容上模仿肿瘤细胞。最近的两个蛋白质组学分析的TEX释放到血浆中的黑色素瘤细胞证实了潜在的TEX作为诊断和预后标志物在黑色素瘤。
Cancer liquid biopsy encompassing circulating tumor cells (CTC), circulating tumor DNA (ctDNA) and/or tumor-derived exosomes (TEX) emerges as a novel approach to early detection, non-invasive monitoring of responses to therapy and predicting patient survival. TEX are a key component of liquid biopsy, because they mimic tumor cells in their proteomic and genetic content. Two recent proteomic analyses of TEX released into plasma by melanoma cells confirms the potential of TEX as diagnostic and prognostic markers in melanoma.