Impaired glucose tolerance is a risk factor per cardiovascular disease, but not impaired fasting glucose - The Funagata diabetes study
Impaired glucose tolerance is a risk factor per cardiovascular disease, but not impaired fasting glucose - The Funagata diabetes study
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DOI：
10.2337/diacare.22.6.920
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发表时间：
1999-06-01
期刊：
影响因子：
16.2
通讯作者：
Sekikawa, A
中科院分区：
文献类型：
--
作者：
Tominaga, M;Eguchi, H;Sekikawa, A
目的 - 确定美国糖尿病协会专家委员会最近提出的新类别空腹血糖受损 (IFG) 是否是心血管疾病的危险因素。 研究设计和方法 - 对 1990-1992 年日本山形县船形市糖尿病患病率研究参与者的队列人群的死亡证明和居住转移文件进行分析，直至 1996 年底。三组：糖耐量正常 (NGT) (n = 2,016)、糖耐量受损 (IGT) (n = 382) 和糖尿病 (n = 253)。然后，同一人群被重新分类为空腹血糖正常 (NFG)、IFG 和糖尿病。采用经典升降台法比较各组间的累积生存率，并采用年龄调整分析、人年法和Cox比例风险模型。 结果：7个观察年末，IGT和糖尿病的心血管疾病累积生存率分别为0.962和0.954，均显着低于NGT（0.988）。 Cox比例风险模型分析显示，IGT与NGT对心血管疾病死亡的风险比为2.219（95% CI 1.076-4.577）。然而，IFG的心血管疾病累积生存率为0.977，并不显着低于NFG（0.985）。 IFG与NFG对心血管疾病死亡的Cox风险比为1.136（0.345-3.734），也不显着。结论——IGT是心血管疾病的危险因素，但IFG不是。
OBJECTIVE - To determine whether the new category of impaired fasting glucose (IFG) recently proposed by the Expert Committee of the American Diabetes Association is a risk factor for cardiovascular disease.RESEARCH DESIGN AND METHODS - Death certificates and residence transfer documents from the cohort population consisting of participants of the diabetes prevalence study in Funagata, Yamagata prefecture, Japan, 1990-1992, were analyzed up through the end of 1996. First, the cohort population was classified into three groups: normal glucose tolerance (NGT) (n = 2,016), impaired glucose tolerance (IGT) (n = 382), and diabetic (n = 253). Then the same population was reclassified into normal fasting glucose (NFG), IFG, and diabetic. The cumulative survival rates among the groups were compared using the classical lift-table method, and age-adjusted analyses, the person-year method, and Cox's proportional hazard model were adopted.RESULTS - At the end of seven observed years, the cumulative survival rates from cardiovascular disease of IGT and diabetes were 0.962 and 0.954, respectively both significantly lower than that of NGT (0.988). The Cox's proportional hazard model analysis showed that the hazard ratio of IGT to NGT on death from cardiovascular disease was 2.219 (95% CI 1.076-4.577). However, the cumulative survival rate of IFG from cardiovascular disease was 0.977, not significantly lower than that of NFG (0.985). The Cox's hazard ratio of IFG to NFG on death from cardiovascular disease was 1.136 (0.345-3.734), which was not significant either.CONCLUSIONS - IGT was a risk factor for cardiovascular disease, but IFG was not.